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Muscle wasting disease: a proposal for a new disease classification
Muscle wasting and cachexia are the ultimate consequence of aging and a variety of acute and chronic illnesses. Significant efforts are made by many stakeholders to develop effective therapies. An important aspect of successful therapeutic development research is a common nomenclature for effective...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953318/ https://www.ncbi.nlm.nih.gov/pubmed/24595459 http://dx.doi.org/10.1007/s13539-014-0135-0 |
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author | Anker, Stefan D. Coats, Andrew J. S. Morley, John E. Rosano, Giuseppe Bernabei, Roberto von Haehling, Stephan Kalantar-Zadeh, Kamyar |
author_facet | Anker, Stefan D. Coats, Andrew J. S. Morley, John E. Rosano, Giuseppe Bernabei, Roberto von Haehling, Stephan Kalantar-Zadeh, Kamyar |
author_sort | Anker, Stefan D. |
collection | PubMed |
description | Muscle wasting and cachexia are the ultimate consequence of aging and a variety of acute and chronic illnesses. Significant efforts are made by many stakeholders to develop effective therapies. An important aspect of successful therapeutic development research is a common nomenclature for effective communication between researchers and clinicians, to the public, and also with regulatory bodies. Despite several efforts to develop consensus definitions for cachexia and sarcopenia, including such new terms for muscle wasting as myopenia, a common conceptual approach and acceptable vocabulary and classification system are yet to be established. Notwithstanding the potential need to translate such disease definitions and terminologies into different languages, we advocate the use of the term “muscle wasting” as the unifying entity that represents the single most common disease process across a large spectrum of cachexia and in sarcopenia-associated disorders. In this paper, we outline a first proposal for the disease nomenclature and classification of “Muscle Wasting Diseases.” This concept can be applied in acute and chronic disease settings. It is pertinent for wasting diseases, cachexia, and sarcopenia of any severity and due to any underlying illness. The concept of muscle wasting disease underscores the most common denominator of the underlying wasting processes, i.e., muscle wasting, without ignoring the advanced disease states that are also accompanied by fat tissue wasting. The term muscle wasting disease is easily understood by both the scientific community and the lay public. This may promote its general use and efforts to heighten education and awareness in the field. |
format | Online Article Text |
id | pubmed-3953318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-39533182014-03-25 Muscle wasting disease: a proposal for a new disease classification Anker, Stefan D. Coats, Andrew J. S. Morley, John E. Rosano, Giuseppe Bernabei, Roberto von Haehling, Stephan Kalantar-Zadeh, Kamyar J Cachexia Sarcopenia Muscle Editorial Muscle wasting and cachexia are the ultimate consequence of aging and a variety of acute and chronic illnesses. Significant efforts are made by many stakeholders to develop effective therapies. An important aspect of successful therapeutic development research is a common nomenclature for effective communication between researchers and clinicians, to the public, and also with regulatory bodies. Despite several efforts to develop consensus definitions for cachexia and sarcopenia, including such new terms for muscle wasting as myopenia, a common conceptual approach and acceptable vocabulary and classification system are yet to be established. Notwithstanding the potential need to translate such disease definitions and terminologies into different languages, we advocate the use of the term “muscle wasting” as the unifying entity that represents the single most common disease process across a large spectrum of cachexia and in sarcopenia-associated disorders. In this paper, we outline a first proposal for the disease nomenclature and classification of “Muscle Wasting Diseases.” This concept can be applied in acute and chronic disease settings. It is pertinent for wasting diseases, cachexia, and sarcopenia of any severity and due to any underlying illness. The concept of muscle wasting disease underscores the most common denominator of the underlying wasting processes, i.e., muscle wasting, without ignoring the advanced disease states that are also accompanied by fat tissue wasting. The term muscle wasting disease is easily understood by both the scientific community and the lay public. This may promote its general use and efforts to heighten education and awareness in the field. Springer Berlin Heidelberg 2014-03-05 2014-03 /pmc/articles/PMC3953318/ /pubmed/24595459 http://dx.doi.org/10.1007/s13539-014-0135-0 Text en © Springer-Verlag Berlin Heidelberg 2014 |
spellingShingle | Editorial Anker, Stefan D. Coats, Andrew J. S. Morley, John E. Rosano, Giuseppe Bernabei, Roberto von Haehling, Stephan Kalantar-Zadeh, Kamyar Muscle wasting disease: a proposal for a new disease classification |
title | Muscle wasting disease: a proposal for a new disease classification |
title_full | Muscle wasting disease: a proposal for a new disease classification |
title_fullStr | Muscle wasting disease: a proposal for a new disease classification |
title_full_unstemmed | Muscle wasting disease: a proposal for a new disease classification |
title_short | Muscle wasting disease: a proposal for a new disease classification |
title_sort | muscle wasting disease: a proposal for a new disease classification |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953318/ https://www.ncbi.nlm.nih.gov/pubmed/24595459 http://dx.doi.org/10.1007/s13539-014-0135-0 |
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