Formulation Optimization of Arecoline Patches

The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K...

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Detalles Bibliográficos
Autores principales: Wu, Pao-Chu, Tsai, Pi-Ju, Lin, Shin-Chen, Huang, Yaw-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953398/
https://www.ncbi.nlm.nih.gov/pubmed/24707220
http://dx.doi.org/10.1155/2014/945168
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author Wu, Pao-Chu
Tsai, Pi-Ju
Lin, Shin-Chen
Huang, Yaw-Bin
author_facet Wu, Pao-Chu
Tsai, Pi-Ju
Lin, Shin-Chen
Huang, Yaw-Bin
author_sort Wu, Pao-Chu
collection PubMed
description The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline.
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spelling pubmed-39533982014-04-06 Formulation Optimization of Arecoline Patches Wu, Pao-Chu Tsai, Pi-Ju Lin, Shin-Chen Huang, Yaw-Bin ScientificWorldJournal Research Article The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline. Hindawi Publishing Corporation 2014-02-23 /pmc/articles/PMC3953398/ /pubmed/24707220 http://dx.doi.org/10.1155/2014/945168 Text en Copyright © 2014 Pao-Chu Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Pao-Chu
Tsai, Pi-Ju
Lin, Shin-Chen
Huang, Yaw-Bin
Formulation Optimization of Arecoline Patches
title Formulation Optimization of Arecoline Patches
title_full Formulation Optimization of Arecoline Patches
title_fullStr Formulation Optimization of Arecoline Patches
title_full_unstemmed Formulation Optimization of Arecoline Patches
title_short Formulation Optimization of Arecoline Patches
title_sort formulation optimization of arecoline patches
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953398/
https://www.ncbi.nlm.nih.gov/pubmed/24707220
http://dx.doi.org/10.1155/2014/945168
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