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Adaptive Gene Amplification As an Intermediate Step in the Expansion of Virus Host Range

The majority of recently emerging infectious diseases in humans is due to cross-species pathogen transmissions from animals. To establish a productive infection in new host species, viruses must overcome barriers to replication mediated by diverse and rapidly evolving host restriction factors such a...

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Detalles Bibliográficos
Autores principales: Brennan, Greg, Kitzman, Jacob O., Rothenburg, Stefan, Shendure, Jay, Geballe, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953438/
https://www.ncbi.nlm.nih.gov/pubmed/24626510
http://dx.doi.org/10.1371/journal.ppat.1004002

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