Trichostatin A Targets the Mitochondrial Respiratory Chain, Increasing Mitochondrial Reactive Oxygen Species Production to Trigger Apoptosis in Human Breast Cancer Cells

AIM: Histone deacetylase inhibitors (HDACIs)-based therapies have stimulated interest via their anti-tumor activities, including apoptosis induction, cell cycle arrest, cell differentiation, and autophagy. However, the mechanisms of HDACI-associated anti-tumor activity are not yet clearly defined. T...

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Detalles Bibliográficos
Autores principales: Sun, Shujuan, Han, Yingyan, Liu, Jia, Fang, Yong, Tian, Yuan, Zhou, Jianfeng, Ma, Ding, Wu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953478/
https://www.ncbi.nlm.nih.gov/pubmed/24626188
http://dx.doi.org/10.1371/journal.pone.0091610

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