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Histone Deacetylase Inhibitor Impairs Plasminogen Activator Inhibitor-1 Expression via Inhibiting TNF-α-Activated MAPK/AP-1 Signaling Cascade

Tumor necrosis factor-(TNF-)-α upregulates plasminogen activator inhibitor-(PAI-) 1 expression in pleural mesothelial cells (PMCs), contributing to fibrin deposition and pleural fibrosis. Histone deacetylases (HDACs) have been found implicated in fibrogenesis. However, the roles of TNF-α or HDAC in...

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Detalles Bibliográficos
Autores principales:	Chen, Wei-Lin, Sheu, Joen-Rong, Hsiao, Che-Jen, Hsiao, Shih-Hsin, Chung, Chi-Li, Hsiao, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953480/ https://www.ncbi.nlm.nih.gov/pubmed/24707477 http://dx.doi.org/10.1155/2014/231012

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