Cargando…
Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels?
Background. A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decre...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953513/ https://www.ncbi.nlm.nih.gov/pubmed/24707500 http://dx.doi.org/10.1155/2014/875438 |
_version_ | 1782307369185705984 |
---|---|
author | Sklavos, Martha M. Spracklen, Cassandra N. Saftlas, Audrey F. Pinto, Ligia A. |
author_facet | Sklavos, Martha M. Spracklen, Cassandra N. Saftlas, Audrey F. Pinto, Ligia A. |
author_sort | Sklavos, Martha M. |
collection | PubMed |
description | Background. A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-Müllerian hormone (AMH), a marker of ovarian reserve. Methods. AMH levels were measured in 18 women treated with LEEP and 18 age-matched controls, who had colposcopy only and did not require LEEP. Cases and controls had their blood drawn at study entry time zero and again 6 months later. Results. The mean AMH level decreased significantly from baseline to follow-up; however, no significant differences were observed when stratifying by LEEP status, suggesting that both groups experienced a similar decrease in AMH levels during the follow-up period. Although women treated with LEEP had lower overall AMH levels than controls at both baseline and follow-up, these differences were not statistically significant. Conclusion. Overall, the delayed time to pregnancy observed in women treated with LEEP is likely not due to a LEEP-associated decrease in ovarian reserve as measured by AMH; thus, other mechanism are responsible for the delayed time to pregnancy associated with LEEP. |
format | Online Article Text |
id | pubmed-3953513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39535132014-04-06 Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels? Sklavos, Martha M. Spracklen, Cassandra N. Saftlas, Audrey F. Pinto, Ligia A. Biomed Res Int Research Article Background. A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-Müllerian hormone (AMH), a marker of ovarian reserve. Methods. AMH levels were measured in 18 women treated with LEEP and 18 age-matched controls, who had colposcopy only and did not require LEEP. Cases and controls had their blood drawn at study entry time zero and again 6 months later. Results. The mean AMH level decreased significantly from baseline to follow-up; however, no significant differences were observed when stratifying by LEEP status, suggesting that both groups experienced a similar decrease in AMH levels during the follow-up period. Although women treated with LEEP had lower overall AMH levels than controls at both baseline and follow-up, these differences were not statistically significant. Conclusion. Overall, the delayed time to pregnancy observed in women treated with LEEP is likely not due to a LEEP-associated decrease in ovarian reserve as measured by AMH; thus, other mechanism are responsible for the delayed time to pregnancy associated with LEEP. Hindawi Publishing Corporation 2014 2014-02-23 /pmc/articles/PMC3953513/ /pubmed/24707500 http://dx.doi.org/10.1155/2014/875438 Text en Copyright © 2014 Martha M. Sklavos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sklavos, Martha M. Spracklen, Cassandra N. Saftlas, Audrey F. Pinto, Ligia A. Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels? |
title | Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels? |
title_full | Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels? |
title_fullStr | Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels? |
title_full_unstemmed | Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels? |
title_short | Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels? |
title_sort | does loop electrosurgical excision procedure of the uterine cervix affect anti-müllerian hormone levels? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953513/ https://www.ncbi.nlm.nih.gov/pubmed/24707500 http://dx.doi.org/10.1155/2014/875438 |
work_keys_str_mv | AT sklavosmartham doesloopelectrosurgicalexcisionprocedureoftheuterinecervixaffectantimullerianhormonelevels AT spracklencassandran doesloopelectrosurgicalexcisionprocedureoftheuterinecervixaffectantimullerianhormonelevels AT saftlasaudreyf doesloopelectrosurgicalexcisionprocedureoftheuterinecervixaffectantimullerianhormonelevels AT pintoligiaa doesloopelectrosurgicalexcisionprocedureoftheuterinecervixaffectantimullerianhormonelevels |