Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

PURPOSE: To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs). METHODS: Relative regional expression of FcRn and localization in human intestinal mucosa...

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Detalles Bibliográficos
Autores principales: Hornby, Pamela J., Cooper, Philip R., Kliwinski, Connie, Ragwan, Edwin, Mabus, John R., Harman, Benjamin, Thompson, Suzanne, Kauffman, Amanda L., Yan, Zhengyin, Tam, Susan H., Dorai, Haimanti, Powers, Gordon D., Giles-Komar, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953555/
https://www.ncbi.nlm.nih.gov/pubmed/24072267
http://dx.doi.org/10.1007/s11095-013-1212-3

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