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Study of a Conformational Equilibrium of Lisinopril by HPLC, NMR, and DFT

The isomerization of lisinopril has been investigated using chromatographic, NMR spectroscopic, and theoretical calculations. The NMR data, particularly the NOEDIFF experiments, show that the major species that was eluted first is the trans form. The proportion was 77% and 23% for the trans and cis,...

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Detalles Bibliográficos
Autores principales: Bouabdallah, Sondes, Ben Dhia, Med Thaieb, Driss, Med Rida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953672/
https://www.ncbi.nlm.nih.gov/pubmed/24707291
http://dx.doi.org/10.1155/2014/494719

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