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Pathologic Collision of Inverted Papilloma with Esthesioneuroblastoma
Background: Inverted papilloma (IP) of the nasal cavity is a benign tumor that represents 0.5–4% of all nasal tumors and have been known to rarely undergo malignant transformation to squamous carcinoma and even more rarely adenocarcinoma. Synchronous association with low-grade esthesioneuroblastoma...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953676/ https://www.ncbi.nlm.nih.gov/pubmed/24672769 http://dx.doi.org/10.3389/fonc.2014.00044 |
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author | Karam, Sana D. Jay, Ann K. Anyanwu, Cynthia Steehler, Matthew K. Davidson, Bruce Debrito, Pedro Harter, K. William |
author_facet | Karam, Sana D. Jay, Ann K. Anyanwu, Cynthia Steehler, Matthew K. Davidson, Bruce Debrito, Pedro Harter, K. William |
author_sort | Karam, Sana D. |
collection | PubMed |
description | Background: Inverted papilloma (IP) of the nasal cavity is a benign tumor that represents 0.5–4% of all nasal tumors and have been known to rarely undergo malignant transformation to squamous carcinoma and even more rarely adenocarcinoma. Synchronous association with low-grade esthesioneuroblastoma (ENB) has been reported in only one case report where a small-sized lesion was treated with surgery alone. Here we report the first case of invasion of IP by high-grade ENB with nodal metastasis that was treated with combined modality therapy. Case Presentation: A case of a 64-year-old African American gentleman presented to the otolaryngology with a 3-month history of recurrent epistaxis. Imaging revealed a large right nasal cavity mass extending into the right sphenoid sinus but without intracranial extension. Surgical pathology revealed high-grade ENB invading IP. An orbitofrontal craniotomy approach was used to achieve complete resection of the mass but with positive margins. Post-operative positron emission tomography/computed tomography showed nodal metastasis. The patient was then treated with adjuvant chemoradiation and remains without evidence of disease at 42 months post-treatment. We discuss the disease presentation, histopathologic features, and disease management with literature support. Conclusion: In this very rare disease presentation where two extremely rare malignancies collide, we show that aggressive management with trimodality therapy of surgery, adjuvant radiation with stereotactic radiosurgical boost, and adjuvant chemotherapy gives excellent results. Given the natural history of the disease, however, long follow-up is needed to declare complete freedom from the disease. |
format | Online Article Text |
id | pubmed-3953676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39536762014-03-26 Pathologic Collision of Inverted Papilloma with Esthesioneuroblastoma Karam, Sana D. Jay, Ann K. Anyanwu, Cynthia Steehler, Matthew K. Davidson, Bruce Debrito, Pedro Harter, K. William Front Oncol Oncology Background: Inverted papilloma (IP) of the nasal cavity is a benign tumor that represents 0.5–4% of all nasal tumors and have been known to rarely undergo malignant transformation to squamous carcinoma and even more rarely adenocarcinoma. Synchronous association with low-grade esthesioneuroblastoma (ENB) has been reported in only one case report where a small-sized lesion was treated with surgery alone. Here we report the first case of invasion of IP by high-grade ENB with nodal metastasis that was treated with combined modality therapy. Case Presentation: A case of a 64-year-old African American gentleman presented to the otolaryngology with a 3-month history of recurrent epistaxis. Imaging revealed a large right nasal cavity mass extending into the right sphenoid sinus but without intracranial extension. Surgical pathology revealed high-grade ENB invading IP. An orbitofrontal craniotomy approach was used to achieve complete resection of the mass but with positive margins. Post-operative positron emission tomography/computed tomography showed nodal metastasis. The patient was then treated with adjuvant chemoradiation and remains without evidence of disease at 42 months post-treatment. We discuss the disease presentation, histopathologic features, and disease management with literature support. Conclusion: In this very rare disease presentation where two extremely rare malignancies collide, we show that aggressive management with trimodality therapy of surgery, adjuvant radiation with stereotactic radiosurgical boost, and adjuvant chemotherapy gives excellent results. Given the natural history of the disease, however, long follow-up is needed to declare complete freedom from the disease. Frontiers Media S.A. 2014-03-14 /pmc/articles/PMC3953676/ /pubmed/24672769 http://dx.doi.org/10.3389/fonc.2014.00044 Text en Copyright © 2014 Karam, Jay, Anyanwu, Steehler, Davidson, Debrito and Harter. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Karam, Sana D. Jay, Ann K. Anyanwu, Cynthia Steehler, Matthew K. Davidson, Bruce Debrito, Pedro Harter, K. William Pathologic Collision of Inverted Papilloma with Esthesioneuroblastoma |
title | Pathologic Collision of Inverted Papilloma with Esthesioneuroblastoma |
title_full | Pathologic Collision of Inverted Papilloma with Esthesioneuroblastoma |
title_fullStr | Pathologic Collision of Inverted Papilloma with Esthesioneuroblastoma |
title_full_unstemmed | Pathologic Collision of Inverted Papilloma with Esthesioneuroblastoma |
title_short | Pathologic Collision of Inverted Papilloma with Esthesioneuroblastoma |
title_sort | pathologic collision of inverted papilloma with esthesioneuroblastoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953676/ https://www.ncbi.nlm.nih.gov/pubmed/24672769 http://dx.doi.org/10.3389/fonc.2014.00044 |
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