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Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored
Recent advances that have been made in our understanding of cancer biology and immunology show that infiltrated immune cells and cytokines in the tumor microenvironment may play different functions that appear tightly related to clinical outcomes. Strategies aimed at interfering with the cross-talk...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953712/ https://www.ncbi.nlm.nih.gov/pubmed/24672524 http://dx.doi.org/10.3389/fimmu.2014.00102 |
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author | de la Cruz-Merino, Luis Illescas-Vacas, Ana Grueso-López, Ana Barco-Sánchez, Antonio Míguez-Sánchez, Carlos |
author_facet | de la Cruz-Merino, Luis Illescas-Vacas, Ana Grueso-López, Ana Barco-Sánchez, Antonio Míguez-Sánchez, Carlos |
author_sort | de la Cruz-Merino, Luis |
collection | PubMed |
description | Recent advances that have been made in our understanding of cancer biology and immunology show that infiltrated immune cells and cytokines in the tumor microenvironment may play different functions that appear tightly related to clinical outcomes. Strategies aimed at interfering with the cross-talk between microenvironment tumor cells and their cellular partners have been considered for the development of new immunotherapies. These novel therapies target different cell components of the tumor microenvironment and importantly, they may be coupled and boosted with classical treatments, such as radiotherapy. In this work, we try to summarize recent data on the microenvironment impact of radiation therapy, from pre-clinical research to the clinic, while taking into account that this new knowledge will probably translate into indication and objective of radiation therapy changes in the next future. |
format | Online Article Text |
id | pubmed-3953712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39537122014-03-26 Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored de la Cruz-Merino, Luis Illescas-Vacas, Ana Grueso-López, Ana Barco-Sánchez, Antonio Míguez-Sánchez, Carlos Front Immunol Immunology Recent advances that have been made in our understanding of cancer biology and immunology show that infiltrated immune cells and cytokines in the tumor microenvironment may play different functions that appear tightly related to clinical outcomes. Strategies aimed at interfering with the cross-talk between microenvironment tumor cells and their cellular partners have been considered for the development of new immunotherapies. These novel therapies target different cell components of the tumor microenvironment and importantly, they may be coupled and boosted with classical treatments, such as radiotherapy. In this work, we try to summarize recent data on the microenvironment impact of radiation therapy, from pre-clinical research to the clinic, while taking into account that this new knowledge will probably translate into indication and objective of radiation therapy changes in the next future. Frontiers Media S.A. 2014-03-14 /pmc/articles/PMC3953712/ /pubmed/24672524 http://dx.doi.org/10.3389/fimmu.2014.00102 Text en Copyright © 2014 de la Cruz-Merino, Illescas-Vacas, Grueso-López, Barco-Sánchez, Míguez-Sánchez and Cancer Immunotherapies Spanish Group (GETICA). http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology de la Cruz-Merino, Luis Illescas-Vacas, Ana Grueso-López, Ana Barco-Sánchez, Antonio Míguez-Sánchez, Carlos Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored |
title | Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored |
title_full | Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored |
title_fullStr | Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored |
title_full_unstemmed | Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored |
title_short | Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored |
title_sort | radiation for awakening the dormant immune system, a promising challenge to be explored |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953712/ https://www.ncbi.nlm.nih.gov/pubmed/24672524 http://dx.doi.org/10.3389/fimmu.2014.00102 |
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