Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE1) inhibitory molecule in rice grain extract and digest

Alzheimer’s disease (AD) is widely considered to be caused by amyloid-β peptide (Aβ) accumulation in the brain. Aβ is excised from amyloid-β precursor protein through sequential cleavage by β-secretase 1 (BACE1) and γ-secretase. Thus, BACE1 inhibition could prevent Aβ accumulation. Here, we identifi...

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Detalles Bibliográficos
Autores principales: Abe, Takako K., Taniguchi, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953730/
https://www.ncbi.nlm.nih.gov/pubmed/24649396
http://dx.doi.org/10.1016/j.fob.2014.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953730/
https://www.ncbi.nlm.nih.gov/pubmed/24649396
http://dx.doi.org/10.1016/j.fob.2014.01.008

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