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New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis
BACKGROUND: Chronic hepatitis C is the most common cause of cirrhosis in industrialized countries. Successful treatment of chronic hepatitis C in patients with advanced fibrosis or cirrhosis has significant benefits, including improvements in inflammation, fibrosis, and portal hypertension, with pre...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953743/ https://www.ncbi.nlm.nih.gov/pubmed/24696626 http://dx.doi.org/10.2147/HMER.S53604 |
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author | Chua, Deborah Lim Hahambis, Thomas Sigal, Samuel H |
author_facet | Chua, Deborah Lim Hahambis, Thomas Sigal, Samuel H |
author_sort | Chua, Deborah Lim |
collection | PubMed |
description | BACKGROUND: Chronic hepatitis C is the most common cause of cirrhosis in industrialized countries. Successful treatment of chronic hepatitis C in patients with advanced fibrosis or cirrhosis has significant benefits, including improvements in inflammation, fibrosis, and portal hypertension, with prevention of esophageal varices and clinical decompensation. CASE: In this report, we present two patients with well-compensated hepatitis C cirrhosis who achieved an end-of-treatment response on a direct-acting antiviral therapy-based triple regimen for hepatitis C virus, but subsequently presented with new-onset ascites associated with virologic relapse. CONCLUSION: We propose that the development of ascites in this setting is due to the adverse impact of inflammation of the virologic relapse on portal hypertension. Our observation that ascites formation can be a manifestation of virologic relapse has potentially important clinical implications, as it highlights not only the importance of close monitoring of cirrhotic patients after achieving end-of-treatment response but also the impact of active inflammation on the severity of portal hypertension. |
format | Online Article Text |
id | pubmed-3953743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-39537432014-04-02 New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis Chua, Deborah Lim Hahambis, Thomas Sigal, Samuel H Hepat Med Case Series BACKGROUND: Chronic hepatitis C is the most common cause of cirrhosis in industrialized countries. Successful treatment of chronic hepatitis C in patients with advanced fibrosis or cirrhosis has significant benefits, including improvements in inflammation, fibrosis, and portal hypertension, with prevention of esophageal varices and clinical decompensation. CASE: In this report, we present two patients with well-compensated hepatitis C cirrhosis who achieved an end-of-treatment response on a direct-acting antiviral therapy-based triple regimen for hepatitis C virus, but subsequently presented with new-onset ascites associated with virologic relapse. CONCLUSION: We propose that the development of ascites in this setting is due to the adverse impact of inflammation of the virologic relapse on portal hypertension. Our observation that ascites formation can be a manifestation of virologic relapse has potentially important clinical implications, as it highlights not only the importance of close monitoring of cirrhotic patients after achieving end-of-treatment response but also the impact of active inflammation on the severity of portal hypertension. Dove Medical Press 2014-01-29 /pmc/articles/PMC3953743/ /pubmed/24696626 http://dx.doi.org/10.2147/HMER.S53604 Text en © 2014 Chua et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Series Chua, Deborah Lim Hahambis, Thomas Sigal, Samuel H New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis |
title | New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis |
title_full | New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis |
title_fullStr | New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis |
title_full_unstemmed | New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis |
title_short | New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis |
title_sort | new-onset ascites as a manifestation of virologic relapse in patients with hepatitis c cirrhosis |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953743/ https://www.ncbi.nlm.nih.gov/pubmed/24696626 http://dx.doi.org/10.2147/HMER.S53604 |
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