Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells

The target of rapamycin (TOR) kinase regulates cell growth and division. Rapamycin only inhibits a subset of TOR activities. Here we show that in contrast to the mild impact of rapamycin on cell division, blocking the catalytic site of TOR with the Torin1 inhibitor completely arrests growth without...

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Detalles Bibliográficos
Autores principales: Atkin, Jane, Halova, Lenka, Ferguson, Jennifer, Hitchin, James R., Lichawska-Cieslar, Agata, Jordan, Allan M., Pines, Jonathon, Wellbrock, Claudia, Petersen, Janni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953821/
https://www.ncbi.nlm.nih.gov/pubmed/24424027
http://dx.doi.org/10.1242/jcs.146373

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