Hydrogen peroxide signaling in vascular endothelial cells

Redox signaling is implicated in different physiological and pathological events in the vasculature. Among the different reactive oxygen species, hydrogen peroxide (H(2)O(2)) is a very good candidate to perform functions as an intracellular messenger in the regulation of several biological events. I...

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Detalles Bibliográficos
Autores principales: Bretón-Romero, Rosa, Lamas, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953958/
https://www.ncbi.nlm.nih.gov/pubmed/24634835
http://dx.doi.org/10.1016/j.redox.2014.02.005
Descripción
Sumario:Redox signaling is implicated in different physiological and pathological events in the vasculature. Among the different reactive oxygen species, hydrogen peroxide (H(2)O(2)) is a very good candidate to perform functions as an intracellular messenger in the regulation of several biological events. In this review, we summarize the main physiological sources of H(2)O(2) in the endothelium and the molecular mechanisms by which it is able to act as a signaling mediator in the vasculature.

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