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Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study

Background. Statins are widely used lipid-lowering drugs with immunomodulatory properties that may favor reactivation of latent varicella-zoster virus infection. However, whether statins increase the risk of herpes zoster is unknown. Methods. We conducted a population-based retrospective cohort stud...

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Autores principales: Antoniou, Tony, Zheng, Hong, Singh, Samantha, Juurlink, David N., Mamdani, Muhammad M., Gomes, Tara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954107/
https://www.ncbi.nlm.nih.gov/pubmed/24235264
http://dx.doi.org/10.1093/cid/cit745
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author Antoniou, Tony
Zheng, Hong
Singh, Samantha
Juurlink, David N.
Mamdani, Muhammad M.
Gomes, Tara
author_facet Antoniou, Tony
Zheng, Hong
Singh, Samantha
Juurlink, David N.
Mamdani, Muhammad M.
Gomes, Tara
author_sort Antoniou, Tony
collection PubMed
description Background. Statins are widely used lipid-lowering drugs with immunomodulatory properties that may favor reactivation of latent varicella-zoster virus infection. However, whether statins increase the risk of herpes zoster is unknown. Methods. We conducted a population-based retrospective cohort study of Ontario residents aged ≥66 years between 1 April 1997 and 31 March 2010 to examine the association between statin use and incidence of herpes zoster. We used propensity score matching to ensure similarity between users and nonusers of statins, and Cox proportional hazard models to assess differences in outcomes between study groups. To test the specificity of our findings, we examined the association between statin exposure and knee arthroplasty. Results. During the 13-year study period, we matched 494 651 individuals treated with a statin to an equal number of untreated individuals. In the main analysis, the rate of herpes zoster was higher among users of statins relative to nonusers of these drugs (13.25 vs 11.71 per 1000 person-years, respectively; hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.10–1.17). The attributable fraction of exposed individuals was 11.6%. In a prespecified analysis, we found a similar risk of herpes zoster among statin users in the subgroup of patients with diabetes (HR, 1.18; 95% CI, 1.09–1.27). As expected, we found no association between statin use and knee arthroplasty (HR, 1.04; 95% CI, .99–1.09). Conclusions. Among older patients, treatment with statins is associated with a small but significantly increased risk of herpes zoster.
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spelling pubmed-39541072014-03-15 Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study Antoniou, Tony Zheng, Hong Singh, Samantha Juurlink, David N. Mamdani, Muhammad M. Gomes, Tara Clin Infect Dis Articles and Commentaries Background. Statins are widely used lipid-lowering drugs with immunomodulatory properties that may favor reactivation of latent varicella-zoster virus infection. However, whether statins increase the risk of herpes zoster is unknown. Methods. We conducted a population-based retrospective cohort study of Ontario residents aged ≥66 years between 1 April 1997 and 31 March 2010 to examine the association between statin use and incidence of herpes zoster. We used propensity score matching to ensure similarity between users and nonusers of statins, and Cox proportional hazard models to assess differences in outcomes between study groups. To test the specificity of our findings, we examined the association between statin exposure and knee arthroplasty. Results. During the 13-year study period, we matched 494 651 individuals treated with a statin to an equal number of untreated individuals. In the main analysis, the rate of herpes zoster was higher among users of statins relative to nonusers of these drugs (13.25 vs 11.71 per 1000 person-years, respectively; hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.10–1.17). The attributable fraction of exposed individuals was 11.6%. In a prespecified analysis, we found a similar risk of herpes zoster among statin users in the subgroup of patients with diabetes (HR, 1.18; 95% CI, 1.09–1.27). As expected, we found no association between statin use and knee arthroplasty (HR, 1.04; 95% CI, .99–1.09). Conclusions. Among older patients, treatment with statins is associated with a small but significantly increased risk of herpes zoster. Oxford University Press 2014-02-01 2013-11-13 /pmc/articles/PMC3954107/ /pubmed/24235264 http://dx.doi.org/10.1093/cid/cit745 Text en © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Articles and Commentaries
Antoniou, Tony
Zheng, Hong
Singh, Samantha
Juurlink, David N.
Mamdani, Muhammad M.
Gomes, Tara
Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study
title Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study
title_full Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study
title_fullStr Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study
title_full_unstemmed Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study
title_short Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study
title_sort statins and the risk of herpes zoster: a population-based cohort study
topic Articles and Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954107/
https://www.ncbi.nlm.nih.gov/pubmed/24235264
http://dx.doi.org/10.1093/cid/cit745
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