MEN 2 syndrome masquerading as MEN 1

Patients with multiple endocrine neoplasia (MEN) type 2A develop medullary thyroid cancer, which is associated with poor prognosis in its metastatic stage. Hyperparathyroidism is a common finding in both MEN 1 and 2. We report a 68-year-old patient diagnosed clinically with MEN 1 based on the presen...

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Detalles Bibliográficos
Autores principales: Tarek, Ezzat, Paramesawaran, Rajeev, Phillips, Ben, Sadler, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal College of Surgeons 2012
Materias:
Online Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954364/
https://www.ncbi.nlm.nih.gov/pubmed/22943324
http://dx.doi.org/10.1308/003588412X13171221590818
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author Tarek, Ezzat
Paramesawaran, Rajeev
Phillips, Ben
Sadler, Greg
author_facet Tarek, Ezzat
Paramesawaran, Rajeev
Phillips, Ben
Sadler, Greg
author_sort Tarek, Ezzat
collection PubMed
description Patients with multiple endocrine neoplasia (MEN) type 2A develop medullary thyroid cancer, which is associated with poor prognosis in its metastatic stage. Hyperparathyroidism is a common finding in both MEN 1 and 2. We report a 68-year-old patient diagnosed clinically with MEN 1 based on the presence of hyperparathyroidism and pituitary Cushing’s disease with no supporting genetic evidence. The hyperparathyroidism was later found to be part of MEN 2A with underlying metastatic medullary thyroid cancer. We highlight the importance of genetic confirmation before a diagnosis of MEN 1 is made as other more serious pathologies might be overlooked.
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spelling pubmed-39543642014-03-19 MEN 2 syndrome masquerading as MEN 1 Tarek, Ezzat Paramesawaran, Rajeev Phillips, Ben Sadler, Greg Ann R Coll Surg Engl Online Case Report Patients with multiple endocrine neoplasia (MEN) type 2A develop medullary thyroid cancer, which is associated with poor prognosis in its metastatic stage. Hyperparathyroidism is a common finding in both MEN 1 and 2. We report a 68-year-old patient diagnosed clinically with MEN 1 based on the presence of hyperparathyroidism and pituitary Cushing’s disease with no supporting genetic evidence. The hyperparathyroidism was later found to be part of MEN 2A with underlying metastatic medullary thyroid cancer. We highlight the importance of genetic confirmation before a diagnosis of MEN 1 is made as other more serious pathologies might be overlooked. Royal College of Surgeons 2012-09 /pmc/articles/PMC3954364/ /pubmed/22943324 http://dx.doi.org/10.1308/003588412X13171221590818 Text en Copyright © 2013 Royal College of Surgeons http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Online Case Report
Tarek, Ezzat
Paramesawaran, Rajeev
Phillips, Ben
Sadler, Greg
MEN 2 syndrome masquerading as MEN 1
title MEN 2 syndrome masquerading as MEN 1
title_full MEN 2 syndrome masquerading as MEN 1
title_fullStr MEN 2 syndrome masquerading as MEN 1
title_full_unstemmed MEN 2 syndrome masquerading as MEN 1
title_short MEN 2 syndrome masquerading as MEN 1
title_sort men 2 syndrome masquerading as men 1
topic Online Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954364/
https://www.ncbi.nlm.nih.gov/pubmed/22943324
http://dx.doi.org/10.1308/003588412X13171221590818
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AT paramesawaranrajeev men2syndromemasqueradingasmen1
AT phillipsben men2syndromemasqueradingasmen1
AT sadlergreg men2syndromemasqueradingasmen1

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