Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N(6)-Substituted-(N)-Methanocarba-nucleosides as A(3) Adenosine Receptor Antagonists and Partial Agonists

[Image: see text] Truncated N(6)-substituted-(N)-methanocarba-adenosine derivatives with 2-hexynyl substitution were synthesized to examine parallels with corresponding 4′-thioadenosines. Hydrophobic N(6) and/or C2 substituents were tolerated in A(3)AR binding, but only an unsubstituted 6-amino grou...

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Detalles Bibliográficos
Autores principales: Nayak, Akshata, Chandra, Girish, Hwang, Inah, Kim, Kyunglim, Hou, Xiyan, Kim, Hea Ok, Sahu, Pramod K., Roy, Kuldeep K., Yoo, Jakyung, Lee, Yoonji, Cui, Minghua, Choi, Sun, Moss, Steven M., Phan, Khai, Gao, Zhan-Guo, Ha, Hunjoo, Jacobson, Kenneth A., Jeong, Lak Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954500/
https://www.ncbi.nlm.nih.gov/pubmed/24456490
http://dx.doi.org/10.1021/jm4015313

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