Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides

[Image: see text] On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal for...

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Autores principales: Lee, Hong Geun, Milner, Phillip J., Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954505/
https://www.ncbi.nlm.nih.gov/pubmed/24559304
http://dx.doi.org/10.1021/ja5009739
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author Lee, Hong Geun
Milner, Phillip J.
Buchwald, Stephen L.
author_facet Lee, Hong Geun
Milner, Phillip J.
Buchwald, Stephen L.
author_sort Lee, Hong Geun
collection PubMed
description [Image: see text] On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.
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spelling pubmed-39545052015-02-21 Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides Lee, Hong Geun Milner, Phillip J. Buchwald, Stephen L. J Am Chem Soc [Image: see text] On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction. American Chemical Society 2014-02-21 2014-03-12 /pmc/articles/PMC3954505/ /pubmed/24559304 http://dx.doi.org/10.1021/ja5009739 Text en Copyright © 2014 American Chemical Society
spellingShingle Lee, Hong Geun
Milner, Phillip J.
Buchwald, Stephen L.
Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
title Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
title_full Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
title_fullStr Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
title_full_unstemmed Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
title_short Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
title_sort pd-catalyzed nucleophilic fluorination of aryl bromides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954505/
https://www.ncbi.nlm.nih.gov/pubmed/24559304
http://dx.doi.org/10.1021/ja5009739
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AT buchwaldstephenl pdcatalyzednucleophilicfluorinationofarylbromides

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