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A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers
BACKGROUND: Asperger Autism is a lifelong psychiatric condition with highly circumscribed interests and routines, problems in social cognition, verbal and nonverbal communication, and also perceptual abnormalities with sensory hypersensitivity. To objectify both lower-level visual and cognitive alte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954585/ https://www.ncbi.nlm.nih.gov/pubmed/24632708 http://dx.doi.org/10.1371/journal.pone.0090993 |
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author | Kornmeier, Juergen Wörner, Rike Riedel, Andreas Bach, Michael Tebartz van Elst, Ludger |
author_facet | Kornmeier, Juergen Wörner, Rike Riedel, Andreas Bach, Michael Tebartz van Elst, Ludger |
author_sort | Kornmeier, Juergen |
collection | PubMed |
description | BACKGROUND: Asperger Autism is a lifelong psychiatric condition with highly circumscribed interests and routines, problems in social cognition, verbal and nonverbal communication, and also perceptual abnormalities with sensory hypersensitivity. To objectify both lower-level visual and cognitive alterations we looked for differences in visual event-related potentials (EEG) between Asperger observers and matched controls while they observed simple checkerboard stimuli. METHODS: In a balanced oddball paradigm checkerboards of two checksizes (0.6° and 1.2°) were presented with different frequencies. Participants counted the occurrence times of the rare fine or rare coarse checkerboards in different experimental conditions. We focused on early visual ERP differences as a function of checkerboard size and the classical P3b ERP component as an indicator of cognitive processing. RESULTS: We found an early (100–200 ms after stimulus onset) occipital ERP effect of checkerboard size (dominant spatial frequency). This effect was weaker in the Asperger than in the control observers. Further a typical parietal/central oddball-P3b occurred at 500 ms with the rare checkerboards. The P3b showed a right-hemispheric lateralization, which was more prominent in Asperger than in control observers. DISCUSSION: The difference in the early occipital ERP effect between the two groups may be a physiological marker of differences in the processing of small visual details in Asperger observers compared to normal controls. The stronger lateralization of the P3b in Asperger observers may indicate a stronger involvement of the right-hemispheric network of bottom-up attention. The lateralization of the P3b signal might be a compensatory consequence of the compromised early checksize effect. Higher-level analytical information processing units may need to compensate for difficulties in low-level signal analysis. |
format | Online Article Text |
id | pubmed-3954585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39545852014-03-18 A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers Kornmeier, Juergen Wörner, Rike Riedel, Andreas Bach, Michael Tebartz van Elst, Ludger PLoS One Research Article BACKGROUND: Asperger Autism is a lifelong psychiatric condition with highly circumscribed interests and routines, problems in social cognition, verbal and nonverbal communication, and also perceptual abnormalities with sensory hypersensitivity. To objectify both lower-level visual and cognitive alterations we looked for differences in visual event-related potentials (EEG) between Asperger observers and matched controls while they observed simple checkerboard stimuli. METHODS: In a balanced oddball paradigm checkerboards of two checksizes (0.6° and 1.2°) were presented with different frequencies. Participants counted the occurrence times of the rare fine or rare coarse checkerboards in different experimental conditions. We focused on early visual ERP differences as a function of checkerboard size and the classical P3b ERP component as an indicator of cognitive processing. RESULTS: We found an early (100–200 ms after stimulus onset) occipital ERP effect of checkerboard size (dominant spatial frequency). This effect was weaker in the Asperger than in the control observers. Further a typical parietal/central oddball-P3b occurred at 500 ms with the rare checkerboards. The P3b showed a right-hemispheric lateralization, which was more prominent in Asperger than in control observers. DISCUSSION: The difference in the early occipital ERP effect between the two groups may be a physiological marker of differences in the processing of small visual details in Asperger observers compared to normal controls. The stronger lateralization of the P3b in Asperger observers may indicate a stronger involvement of the right-hemispheric network of bottom-up attention. The lateralization of the P3b signal might be a compensatory consequence of the compromised early checksize effect. Higher-level analytical information processing units may need to compensate for difficulties in low-level signal analysis. Public Library of Science 2014-03-14 /pmc/articles/PMC3954585/ /pubmed/24632708 http://dx.doi.org/10.1371/journal.pone.0090993 Text en © 2014 Kornmeier et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kornmeier, Juergen Wörner, Rike Riedel, Andreas Bach, Michael Tebartz van Elst, Ludger A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers |
title | A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers |
title_full | A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers |
title_fullStr | A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers |
title_full_unstemmed | A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers |
title_short | A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers |
title_sort | different view on the checkerboard? alterations in early and late visually evoked eeg potentials in asperger observers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954585/ https://www.ncbi.nlm.nih.gov/pubmed/24632708 http://dx.doi.org/10.1371/journal.pone.0090993 |
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