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Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

Monoclonal antibody producing Chinese hamster ovary (CHO) cells have been shown to undergo metabolic changes when engineered to produce high titers of recombinant proteins. In this work, we have studied the distinct metabolism of CHO cell clones harboring an efficient inducible expression system, ba...

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Detalles Bibliográficos
Autores principales:	Ghorbaniaghdam, Atefeh, Chen, Jingkui, Henry, Olivier, Jolicoeur, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954614/ https://www.ncbi.nlm.nih.gov/pubmed/24632968 http://dx.doi.org/10.1371/journal.pone.0090832

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