BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint

The B cell-specific transcription factor BACH2 is required for affinity maturation of mature B cells. Here, we show that Bach2-mediated activation of p53 is required for stringent elimination of pre-B cells that failed to productively rearrange immunoglobulin V(H)-DJ(H) gene segments. Upon productiv...

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Detalles Bibliográficos
Autores principales: Swaminathan, Srividya, Huang, Chuanxin, Geng, Huimin, Chen, Zhengshan, Harvey, Richard, Kang, Huining, Ng, Carina, Titz, Björn, Hurtz, Christian, Sadiyah, Mohammed Firas, Nowak, Daniel, Thoennissen, Gabriela B., Rand, Vikki, Graeber, Thomas G., Koeffler, H. Phillip, Carroll, William L, Willman, Cheryl L, Hall, Andrew G., Igarashi, Kazuhiko, Melnick, Ari, Müschen, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954721/
https://www.ncbi.nlm.nih.gov/pubmed/23852341
http://dx.doi.org/10.1038/nm.3247

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