Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation

In the present study, we observed a marked variation in the expression of PKCα and PKCδ isotypes in B16F10 melanoma tumor cells compared to the normal melanocytes. Interestingly, the tumor instructed expression or genetically manipulated overexpression of PKCα isotype resulted in enhanced G1 to S tr...

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Detalles Bibliográficos
Autores principales: Halder, Kuntal, Banerjee, Sayantan, Bose, Anamika, Majumder, Saikat, Majumdar, Subrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954766/
https://www.ncbi.nlm.nih.gov/pubmed/24632809
http://dx.doi.org/10.1371/journal.pone.0091656

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