Monoallelic Germline TSC1 Mutations Are Permissive for T Lymphocyte Development and Homeostasis in Tuberous Sclerosis Complex Individuals

Germline and somatic biallelic mutations of the Tuberous sclerosis complex (TSC) 1 and TSC2 gene products cause TSC, an autosomal dominant multifocal hamartomatosis with variable neurological manifestations. The consequences of TSC1 or TSC2 loss in cells of hematopoietic origin have recently started...

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Detalles Bibliográficos
Autores principales: Pilipow, Karolina, Basso, Veronica, Migone, Nicola, Mondino, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954840/
https://www.ncbi.nlm.nih.gov/pubmed/24633152
http://dx.doi.org/10.1371/journal.pone.0091952

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