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The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines

Intravenous application of high-dose ascorbate is used in complementary palliative medicine to treat cancer patients. Pharmacological doses of ascorbate in the mM range induce cytotoxicity in cancer cells mediated by reactive oxygen species (ROS), namely hydrogen peroxide and ascorbyl radicals. Howe...

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Detalles Bibliográficos
Autores principales:	Sinnberg, Tobias, Noor, Seema, Venturelli, Sascha, Berger, Alexander, Schuler, Paul, Garbe, Claus, Busch, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955158/ https://www.ncbi.nlm.nih.gov/pubmed/24330097 http://dx.doi.org/10.1111/jcmm.12207

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