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Renal Allograft Nephrectomy: Comparison Between Clinical and Pathological Diagnosis
BACKGROUND AND AIM: The most common complication of renal transplantation is allograft dysfunction, which in some cases leads to graft loss. The role of graft nephrectomy in the management of transplant failure is controversial. The procedure remains associated with a significant morbidity and also...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955278/ https://www.ncbi.nlm.nih.gov/pubmed/24693511 http://dx.doi.org/10.5812/numonthly.10596 |
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author | Panahi, Ali Bidaki, Reza Mirhosseini, Seyyed Mohammad Mahdy Mehraban, Darab |
author_facet | Panahi, Ali Bidaki, Reza Mirhosseini, Seyyed Mohammad Mahdy Mehraban, Darab |
author_sort | Panahi, Ali |
collection | PubMed |
description | BACKGROUND AND AIM: The most common complication of renal transplantation is allograft dysfunction, which in some cases leads to graft loss. The role of graft nephrectomy in the management of transplant failure is controversial. The procedure remains associated with a significant morbidity and also mortality. Our main purpose was the comparison between clinical and pathological diagnosis of graft nephrectomy. PATIENTS AND METHODS: The documents of 88 patients who admitted for graft nephrectomy in Shariaty hospital for the last 25 years were reviewed. Slides of graft pathology were revised by an individual nephropathologist. Data was analyzed by SPSS 18 using ANOVA and Chi-square tests. RESULTS: The percentages of clinical diagnoses for the graft nephrectomy are: chronic rejection (38%), graft infection (26%), gross hematuria (10%), acute rejection (10%), accelerated rejection (8%), hyper-acute rejection (4%) and thrombosis of the renal artery (4). On the other hand, the pathological diagnoses are: necrosis concomitant with thrombosis (35%), only necrosis (26%) and 5 (3) concomitant with 4 (3) in 16% of cases that means severe interstitial atrophy and fibrosis adjacent with acute cellular rejection and intramural vasculitis. CONCLUSIONS: Pathology included necrosis in about half of the graft nephrectomized patients. If the panel reactivity test is negative preoperatively, and there is no absolute indication for the operation, one may abstain from graft nephrectomy to save the patient, the morbidity and even the mortality of the procedure. On the other hand, the advantages of leaving the graft in situ are erythropoietin production, hydroxylation of calcidiol and maintenance of some residual diuresis. |
format | Online Article Text |
id | pubmed-3955278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-39552782014-04-01 Renal Allograft Nephrectomy: Comparison Between Clinical and Pathological Diagnosis Panahi, Ali Bidaki, Reza Mirhosseini, Seyyed Mohammad Mahdy Mehraban, Darab Nephrourol Mon Brief Report BACKGROUND AND AIM: The most common complication of renal transplantation is allograft dysfunction, which in some cases leads to graft loss. The role of graft nephrectomy in the management of transplant failure is controversial. The procedure remains associated with a significant morbidity and also mortality. Our main purpose was the comparison between clinical and pathological diagnosis of graft nephrectomy. PATIENTS AND METHODS: The documents of 88 patients who admitted for graft nephrectomy in Shariaty hospital for the last 25 years were reviewed. Slides of graft pathology were revised by an individual nephropathologist. Data was analyzed by SPSS 18 using ANOVA and Chi-square tests. RESULTS: The percentages of clinical diagnoses for the graft nephrectomy are: chronic rejection (38%), graft infection (26%), gross hematuria (10%), acute rejection (10%), accelerated rejection (8%), hyper-acute rejection (4%) and thrombosis of the renal artery (4). On the other hand, the pathological diagnoses are: necrosis concomitant with thrombosis (35%), only necrosis (26%) and 5 (3) concomitant with 4 (3) in 16% of cases that means severe interstitial atrophy and fibrosis adjacent with acute cellular rejection and intramural vasculitis. CONCLUSIONS: Pathology included necrosis in about half of the graft nephrectomized patients. If the panel reactivity test is negative preoperatively, and there is no absolute indication for the operation, one may abstain from graft nephrectomy to save the patient, the morbidity and even the mortality of the procedure. On the other hand, the advantages of leaving the graft in situ are erythropoietin production, hydroxylation of calcidiol and maintenance of some residual diuresis. Kowsar 2013-11-13 2013-11 /pmc/articles/PMC3955278/ /pubmed/24693511 http://dx.doi.org/10.5812/numonthly.10596 Text en Copyright © 2013, Nephrology and Urology Research Center; Published by Kowsar Corp. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Panahi, Ali Bidaki, Reza Mirhosseini, Seyyed Mohammad Mahdy Mehraban, Darab Renal Allograft Nephrectomy: Comparison Between Clinical and Pathological Diagnosis |
title | Renal Allograft Nephrectomy: Comparison Between Clinical and Pathological Diagnosis |
title_full | Renal Allograft Nephrectomy: Comparison Between Clinical and Pathological Diagnosis |
title_fullStr | Renal Allograft Nephrectomy: Comparison Between Clinical and Pathological Diagnosis |
title_full_unstemmed | Renal Allograft Nephrectomy: Comparison Between Clinical and Pathological Diagnosis |
title_short | Renal Allograft Nephrectomy: Comparison Between Clinical and Pathological Diagnosis |
title_sort | renal allograft nephrectomy: comparison between clinical and pathological diagnosis |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955278/ https://www.ncbi.nlm.nih.gov/pubmed/24693511 http://dx.doi.org/10.5812/numonthly.10596 |
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