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Multiple A2E treatments lead to melanization of rod outer segment–challenged ARPE-19 cells

PURPOSE: Daily phagocytosis of outer segments (OSs) and retinoid recycling by the RPE lead to the accumulation of storage bodies in the RPE containing autofluorescent lipofuscin, which consists of lipids and bisretinoids such as A2E and its oxidation products. Accumulation of A2E and its oxidation p...

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Detalles Bibliográficos
Autores principales:	Poliakov, Eugenia, Strunnikova, Natalya V., Jiang, Jian-kang, Martinez, Bianca, Parikh, Toral, Lakkaraju, Aparna, Thomas, Craig, Brooks, Brian P., Redmond, T. Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955416/ https://www.ncbi.nlm.nih.gov/pubmed/24644403

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