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Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since...

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Detalles Bibliográficos
Autores principales: Aparecida da Silva, Crislaine, Molinar Mauad Cintra, Mariana, de Castro Côbo, Eliângela, Vinícius da Silva, Marcos, Bichuette Custódio, Fabiano, Rosa Miranda Corrêa, Rosana, Roberto Castellano, Lúcio, Antônia dos Reis, Marlene, Reis Machado, Juliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955602/
https://www.ncbi.nlm.nih.gov/pubmed/24719498
http://dx.doi.org/10.1155/2014/192836
Descripción
Sumario:Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis.