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Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since...

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Autores principales: Aparecida da Silva, Crislaine, Molinar Mauad Cintra, Mariana, de Castro Côbo, Eliângela, Vinícius da Silva, Marcos, Bichuette Custódio, Fabiano, Rosa Miranda Corrêa, Rosana, Roberto Castellano, Lúcio, Antônia dos Reis, Marlene, Reis Machado, Juliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955602/
https://www.ncbi.nlm.nih.gov/pubmed/24719498
http://dx.doi.org/10.1155/2014/192836
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author Aparecida da Silva, Crislaine
Molinar Mauad Cintra, Mariana
de Castro Côbo, Eliângela
Vinícius da Silva, Marcos
Bichuette Custódio, Fabiano
Rosa Miranda Corrêa, Rosana
Roberto Castellano, Lúcio
Antônia dos Reis, Marlene
Reis Machado, Juliana
author_facet Aparecida da Silva, Crislaine
Molinar Mauad Cintra, Mariana
de Castro Côbo, Eliângela
Vinícius da Silva, Marcos
Bichuette Custódio, Fabiano
Rosa Miranda Corrêa, Rosana
Roberto Castellano, Lúcio
Antônia dos Reis, Marlene
Reis Machado, Juliana
author_sort Aparecida da Silva, Crislaine
collection PubMed
description Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis.
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spelling pubmed-39556022014-04-09 Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis Aparecida da Silva, Crislaine Molinar Mauad Cintra, Mariana de Castro Côbo, Eliângela Vinícius da Silva, Marcos Bichuette Custódio, Fabiano Rosa Miranda Corrêa, Rosana Roberto Castellano, Lúcio Antônia dos Reis, Marlene Reis Machado, Juliana Dis Markers Review Article Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis. Hindawi Publishing Corporation 2014 2014-02-25 /pmc/articles/PMC3955602/ /pubmed/24719498 http://dx.doi.org/10.1155/2014/192836 Text en Copyright © 2014 Crislaine Aparecida da Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Aparecida da Silva, Crislaine
Molinar Mauad Cintra, Mariana
de Castro Côbo, Eliângela
Vinícius da Silva, Marcos
Bichuette Custódio, Fabiano
Rosa Miranda Corrêa, Rosana
Roberto Castellano, Lúcio
Antônia dos Reis, Marlene
Reis Machado, Juliana
Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis
title Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis
title_full Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis
title_fullStr Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis
title_full_unstemmed Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis
title_short Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis
title_sort renal biopsy: use of biomarkers as a tool for the diagnosis of focal segmental glomerulosclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955602/
https://www.ncbi.nlm.nih.gov/pubmed/24719498
http://dx.doi.org/10.1155/2014/192836
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