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Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955602/ https://www.ncbi.nlm.nih.gov/pubmed/24719498 http://dx.doi.org/10.1155/2014/192836 |
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author | Aparecida da Silva, Crislaine Molinar Mauad Cintra, Mariana de Castro Côbo, Eliângela Vinícius da Silva, Marcos Bichuette Custódio, Fabiano Rosa Miranda Corrêa, Rosana Roberto Castellano, Lúcio Antônia dos Reis, Marlene Reis Machado, Juliana |
author_facet | Aparecida da Silva, Crislaine Molinar Mauad Cintra, Mariana de Castro Côbo, Eliângela Vinícius da Silva, Marcos Bichuette Custódio, Fabiano Rosa Miranda Corrêa, Rosana Roberto Castellano, Lúcio Antônia dos Reis, Marlene Reis Machado, Juliana |
author_sort | Aparecida da Silva, Crislaine |
collection | PubMed |
description | Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis. |
format | Online Article Text |
id | pubmed-3955602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39556022014-04-09 Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis Aparecida da Silva, Crislaine Molinar Mauad Cintra, Mariana de Castro Côbo, Eliângela Vinícius da Silva, Marcos Bichuette Custódio, Fabiano Rosa Miranda Corrêa, Rosana Roberto Castellano, Lúcio Antônia dos Reis, Marlene Reis Machado, Juliana Dis Markers Review Article Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis. Hindawi Publishing Corporation 2014 2014-02-25 /pmc/articles/PMC3955602/ /pubmed/24719498 http://dx.doi.org/10.1155/2014/192836 Text en Copyright © 2014 Crislaine Aparecida da Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Aparecida da Silva, Crislaine Molinar Mauad Cintra, Mariana de Castro Côbo, Eliângela Vinícius da Silva, Marcos Bichuette Custódio, Fabiano Rosa Miranda Corrêa, Rosana Roberto Castellano, Lúcio Antônia dos Reis, Marlene Reis Machado, Juliana Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis |
title | Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis |
title_full | Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis |
title_fullStr | Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis |
title_full_unstemmed | Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis |
title_short | Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis |
title_sort | renal biopsy: use of biomarkers as a tool for the diagnosis of focal segmental glomerulosclerosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955602/ https://www.ncbi.nlm.nih.gov/pubmed/24719498 http://dx.doi.org/10.1155/2014/192836 |
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