RANKL Expression in Periodontal Disease: Where Does RANKL Come from?

Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development...

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Detalles Bibliográficos
Autores principales: Chen, Bin, Wu, Wenlei, Sun, Weibin, Zhang, Qian, Yan, Fuhua, Xiao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955606/
https://www.ncbi.nlm.nih.gov/pubmed/24719884
http://dx.doi.org/10.1155/2014/731039
Descripción
Sumario:Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.

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