RANKL Expression in Periodontal Disease: Where Does RANKL Come from?

Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development...

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Detalles Bibliográficos
Autores principales: Chen, Bin, Wu, Wenlei, Sun, Weibin, Zhang, Qian, Yan, Fuhua, Xiao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955606/
https://www.ncbi.nlm.nih.gov/pubmed/24719884
http://dx.doi.org/10.1155/2014/731039
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author Chen, Bin
Wu, Wenlei
Sun, Weibin
Zhang, Qian
Yan, Fuhua
Xiao, Yin
author_facet Chen, Bin
Wu, Wenlei
Sun, Weibin
Zhang, Qian
Yan, Fuhua
Xiao, Yin
author_sort Chen, Bin
collection PubMed
description Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.
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spelling pubmed-39556062014-04-09 RANKL Expression in Periodontal Disease: Where Does RANKL Come from? Chen, Bin Wu, Wenlei Sun, Weibin Zhang, Qian Yan, Fuhua Xiao, Yin Biomed Res Int Review Article Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease. Hindawi Publishing Corporation 2014 2014-02-27 /pmc/articles/PMC3955606/ /pubmed/24719884 http://dx.doi.org/10.1155/2014/731039 Text en Copyright © 2014 Bin Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Bin
Wu, Wenlei
Sun, Weibin
Zhang, Qian
Yan, Fuhua
Xiao, Yin
RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
title RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
title_full RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
title_fullStr RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
title_full_unstemmed RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
title_short RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
title_sort rankl expression in periodontal disease: where does rankl come from?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955606/
https://www.ncbi.nlm.nih.gov/pubmed/24719884
http://dx.doi.org/10.1155/2014/731039
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