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Stem Cell-Based Therapies for Ischemic Stroke

In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem...

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Detalles Bibliográficos
Autores principales: Hao, Lei, Zou, Zhongmin, Tian, Hong, Zhang, Yubo, Zhou, Huchuan, Liu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955655/
https://www.ncbi.nlm.nih.gov/pubmed/24719869
http://dx.doi.org/10.1155/2014/468748
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author Hao, Lei
Zou, Zhongmin
Tian, Hong
Zhang, Yubo
Zhou, Huchuan
Liu, Lei
author_facet Hao, Lei
Zou, Zhongmin
Tian, Hong
Zhang, Yubo
Zhou, Huchuan
Liu, Lei
author_sort Hao, Lei
collection PubMed
description In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem cells (iPSCs), neural stem cells (NSCs), and mesenchymal stem cell (MSCs) might be due to cell replacement, neuroprotection, endogenous neurogenesis, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed. Undoubtably, stem cell-based gene therapy represents a novel potential therapeutic strategy for stroke in future.
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spelling pubmed-39556552014-04-09 Stem Cell-Based Therapies for Ischemic Stroke Hao, Lei Zou, Zhongmin Tian, Hong Zhang, Yubo Zhou, Huchuan Liu, Lei Biomed Res Int Review Article In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem cells (iPSCs), neural stem cells (NSCs), and mesenchymal stem cell (MSCs) might be due to cell replacement, neuroprotection, endogenous neurogenesis, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed. Undoubtably, stem cell-based gene therapy represents a novel potential therapeutic strategy for stroke in future. Hindawi Publishing Corporation 2014 2014-02-26 /pmc/articles/PMC3955655/ /pubmed/24719869 http://dx.doi.org/10.1155/2014/468748 Text en Copyright © 2014 Lei Hao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hao, Lei
Zou, Zhongmin
Tian, Hong
Zhang, Yubo
Zhou, Huchuan
Liu, Lei
Stem Cell-Based Therapies for Ischemic Stroke
title Stem Cell-Based Therapies for Ischemic Stroke
title_full Stem Cell-Based Therapies for Ischemic Stroke
title_fullStr Stem Cell-Based Therapies for Ischemic Stroke
title_full_unstemmed Stem Cell-Based Therapies for Ischemic Stroke
title_short Stem Cell-Based Therapies for Ischemic Stroke
title_sort stem cell-based therapies for ischemic stroke
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955655/
https://www.ncbi.nlm.nih.gov/pubmed/24719869
http://dx.doi.org/10.1155/2014/468748
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