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Stem Cell-Based Therapies for Ischemic Stroke
In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955655/ https://www.ncbi.nlm.nih.gov/pubmed/24719869 http://dx.doi.org/10.1155/2014/468748 |
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author | Hao, Lei Zou, Zhongmin Tian, Hong Zhang, Yubo Zhou, Huchuan Liu, Lei |
author_facet | Hao, Lei Zou, Zhongmin Tian, Hong Zhang, Yubo Zhou, Huchuan Liu, Lei |
author_sort | Hao, Lei |
collection | PubMed |
description | In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem cells (iPSCs), neural stem cells (NSCs), and mesenchymal stem cell (MSCs) might be due to cell replacement, neuroprotection, endogenous neurogenesis, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed. Undoubtably, stem cell-based gene therapy represents a novel potential therapeutic strategy for stroke in future. |
format | Online Article Text |
id | pubmed-3955655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39556552014-04-09 Stem Cell-Based Therapies for Ischemic Stroke Hao, Lei Zou, Zhongmin Tian, Hong Zhang, Yubo Zhou, Huchuan Liu, Lei Biomed Res Int Review Article In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem cells (iPSCs), neural stem cells (NSCs), and mesenchymal stem cell (MSCs) might be due to cell replacement, neuroprotection, endogenous neurogenesis, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed. Undoubtably, stem cell-based gene therapy represents a novel potential therapeutic strategy for stroke in future. Hindawi Publishing Corporation 2014 2014-02-26 /pmc/articles/PMC3955655/ /pubmed/24719869 http://dx.doi.org/10.1155/2014/468748 Text en Copyright © 2014 Lei Hao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hao, Lei Zou, Zhongmin Tian, Hong Zhang, Yubo Zhou, Huchuan Liu, Lei Stem Cell-Based Therapies for Ischemic Stroke |
title | Stem Cell-Based Therapies for Ischemic Stroke |
title_full | Stem Cell-Based Therapies for Ischemic Stroke |
title_fullStr | Stem Cell-Based Therapies for Ischemic Stroke |
title_full_unstemmed | Stem Cell-Based Therapies for Ischemic Stroke |
title_short | Stem Cell-Based Therapies for Ischemic Stroke |
title_sort | stem cell-based therapies for ischemic stroke |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955655/ https://www.ncbi.nlm.nih.gov/pubmed/24719869 http://dx.doi.org/10.1155/2014/468748 |
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