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Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression

Late-life depression could be classified roughly as early-onset depression (EOD) and late-onset depression (LOD). LOD was proved to be associated with cerebral lesions including white matter hyperintensities (WMH) and silent brain infarctions (SBI), differently from EOD. However, it is unclear wheth...

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Autores principales: Feng, Chao, Fang, Min, Xu, Yu, Hua, Ting, Liu, Xue-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955674/
https://www.ncbi.nlm.nih.gov/pubmed/24719883
http://dx.doi.org/10.1155/2014/682092
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author Feng, Chao
Fang, Min
Xu, Yu
Hua, Ting
Liu, Xue-Yuan
author_facet Feng, Chao
Fang, Min
Xu, Yu
Hua, Ting
Liu, Xue-Yuan
author_sort Feng, Chao
collection PubMed
description Late-life depression could be classified roughly as early-onset depression (EOD) and late-onset depression (LOD). LOD was proved to be associated with cerebral lesions including white matter hyperintensities (WMH) and silent brain infarctions (SBI), differently from EOD. However, it is unclear whether similar association is present between LOD and microbleeds which are also silent lesions. In this study, 195 patients of late-life depression were evaluated and divided into EOD, presenile-onset depression (POD), and LOD groups; 85 healthy elderly controls were enrolled as controls. Subjects were scanned by MRI including susceptibility weighted images to evaluate white matter hyperintensities (WMH), silent brain infarctions (SBI), and microbleeds. The severity of depression was evaluated with 15-item Geriatric Depression Scale. Psychosocial factors were investigated with Scale of Life Events and Lubben Social Network Scale. Logistic regression and linear regression were performed to identify the independent risk factors for depression. Results showed that LOD patients had higher prevalence of microbleeds than EOD, POD, and control patients. The prevalence of lobar microbleeds and microbleeds in the left hemisphere was the independent risk factor for the occurrence of LOD; a high number of microbleeds were associated with severe state of LOD, whereas life events and lack of social support were more important for EOD and POD. All these results indicated that Microbleeds especially lobar microbleeds and microbleeds in the left hemisphere were associated with LOD but not with EOD.
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spelling pubmed-39556742014-04-09 Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression Feng, Chao Fang, Min Xu, Yu Hua, Ting Liu, Xue-Yuan Biomed Res Int Clinical Study Late-life depression could be classified roughly as early-onset depression (EOD) and late-onset depression (LOD). LOD was proved to be associated with cerebral lesions including white matter hyperintensities (WMH) and silent brain infarctions (SBI), differently from EOD. However, it is unclear whether similar association is present between LOD and microbleeds which are also silent lesions. In this study, 195 patients of late-life depression were evaluated and divided into EOD, presenile-onset depression (POD), and LOD groups; 85 healthy elderly controls were enrolled as controls. Subjects were scanned by MRI including susceptibility weighted images to evaluate white matter hyperintensities (WMH), silent brain infarctions (SBI), and microbleeds. The severity of depression was evaluated with 15-item Geriatric Depression Scale. Psychosocial factors were investigated with Scale of Life Events and Lubben Social Network Scale. Logistic regression and linear regression were performed to identify the independent risk factors for depression. Results showed that LOD patients had higher prevalence of microbleeds than EOD, POD, and control patients. The prevalence of lobar microbleeds and microbleeds in the left hemisphere was the independent risk factor for the occurrence of LOD; a high number of microbleeds were associated with severe state of LOD, whereas life events and lack of social support were more important for EOD and POD. All these results indicated that Microbleeds especially lobar microbleeds and microbleeds in the left hemisphere were associated with LOD but not with EOD. Hindawi Publishing Corporation 2014 2014-02-26 /pmc/articles/PMC3955674/ /pubmed/24719883 http://dx.doi.org/10.1155/2014/682092 Text en Copyright © 2014 Chao Feng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Feng, Chao
Fang, Min
Xu, Yu
Hua, Ting
Liu, Xue-Yuan
Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression
title Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression
title_full Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression
title_fullStr Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression
title_full_unstemmed Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression
title_short Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression
title_sort microbleeds in late-life depression: comparison of early- and late-onset depression
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955674/
https://www.ncbi.nlm.nih.gov/pubmed/24719883
http://dx.doi.org/10.1155/2014/682092
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