Cargando…
Telomere Length Reprogramming in Embryos and Stem Cells
Telomeres protect and cap linear chromosome ends, yet these genomic buffers erode over an organism's lifespan. Short telomeres have been associated with many age-related conditions in humans, and genetic mutations resulting in short telomeres in humans manifest as syndromes of precocious aging....
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955682/ https://www.ncbi.nlm.nih.gov/pubmed/24719895 http://dx.doi.org/10.1155/2014/925121 |
_version_ | 1782307613487136768 |
---|---|
author | Kalmbach, Keri Robinson, LeRoy G. Wang, Fang Liu, Lin Keefe, David |
author_facet | Kalmbach, Keri Robinson, LeRoy G. Wang, Fang Liu, Lin Keefe, David |
author_sort | Kalmbach, Keri |
collection | PubMed |
description | Telomeres protect and cap linear chromosome ends, yet these genomic buffers erode over an organism's lifespan. Short telomeres have been associated with many age-related conditions in humans, and genetic mutations resulting in short telomeres in humans manifest as syndromes of precocious aging. In women, telomere length limits a fertilized egg's capacity to develop into a healthy embryo. Thus, telomere length must be reset with each subsequent generation. Although telomerase is purportedly responsible for restoring telomere DNA, recent studies have elucidated the role of alternative telomeres lengthening mechanisms in the reprogramming of early embryos and stem cells, which we review here. |
format | Online Article Text |
id | pubmed-3955682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39556822014-04-09 Telomere Length Reprogramming in Embryos and Stem Cells Kalmbach, Keri Robinson, LeRoy G. Wang, Fang Liu, Lin Keefe, David Biomed Res Int Review Article Telomeres protect and cap linear chromosome ends, yet these genomic buffers erode over an organism's lifespan. Short telomeres have been associated with many age-related conditions in humans, and genetic mutations resulting in short telomeres in humans manifest as syndromes of precocious aging. In women, telomere length limits a fertilized egg's capacity to develop into a healthy embryo. Thus, telomere length must be reset with each subsequent generation. Although telomerase is purportedly responsible for restoring telomere DNA, recent studies have elucidated the role of alternative telomeres lengthening mechanisms in the reprogramming of early embryos and stem cells, which we review here. Hindawi Publishing Corporation 2014 2014-02-27 /pmc/articles/PMC3955682/ /pubmed/24719895 http://dx.doi.org/10.1155/2014/925121 Text en Copyright © 2014 Keri Kalmbach et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kalmbach, Keri Robinson, LeRoy G. Wang, Fang Liu, Lin Keefe, David Telomere Length Reprogramming in Embryos and Stem Cells |
title | Telomere Length Reprogramming in Embryos and Stem Cells |
title_full | Telomere Length Reprogramming in Embryos and Stem Cells |
title_fullStr | Telomere Length Reprogramming in Embryos and Stem Cells |
title_full_unstemmed | Telomere Length Reprogramming in Embryos and Stem Cells |
title_short | Telomere Length Reprogramming in Embryos and Stem Cells |
title_sort | telomere length reprogramming in embryos and stem cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955682/ https://www.ncbi.nlm.nih.gov/pubmed/24719895 http://dx.doi.org/10.1155/2014/925121 |
work_keys_str_mv | AT kalmbachkeri telomerelengthreprogramminginembryosandstemcells AT robinsonleroyg telomerelengthreprogramminginembryosandstemcells AT wangfang telomerelengthreprogramminginembryosandstemcells AT liulin telomerelengthreprogramminginembryosandstemcells AT keefedavid telomerelengthreprogramminginembryosandstemcells |