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Telomere Length Reprogramming in Embryos and Stem Cells

Telomeres protect and cap linear chromosome ends, yet these genomic buffers erode over an organism's lifespan. Short telomeres have been associated with many age-related conditions in humans, and genetic mutations resulting in short telomeres in humans manifest as syndromes of precocious aging....

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Detalles Bibliográficos
Autores principales: Kalmbach, Keri, Robinson, LeRoy G., Wang, Fang, Liu, Lin, Keefe, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955682/
https://www.ncbi.nlm.nih.gov/pubmed/24719895
http://dx.doi.org/10.1155/2014/925121
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author Kalmbach, Keri
Robinson, LeRoy G.
Wang, Fang
Liu, Lin
Keefe, David
author_facet Kalmbach, Keri
Robinson, LeRoy G.
Wang, Fang
Liu, Lin
Keefe, David
author_sort Kalmbach, Keri
collection PubMed
description Telomeres protect and cap linear chromosome ends, yet these genomic buffers erode over an organism's lifespan. Short telomeres have been associated with many age-related conditions in humans, and genetic mutations resulting in short telomeres in humans manifest as syndromes of precocious aging. In women, telomere length limits a fertilized egg's capacity to develop into a healthy embryo. Thus, telomere length must be reset with each subsequent generation. Although telomerase is purportedly responsible for restoring telomere DNA, recent studies have elucidated the role of alternative telomeres lengthening mechanisms in the reprogramming of early embryos and stem cells, which we review here.
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spelling pubmed-39556822014-04-09 Telomere Length Reprogramming in Embryos and Stem Cells Kalmbach, Keri Robinson, LeRoy G. Wang, Fang Liu, Lin Keefe, David Biomed Res Int Review Article Telomeres protect and cap linear chromosome ends, yet these genomic buffers erode over an organism's lifespan. Short telomeres have been associated with many age-related conditions in humans, and genetic mutations resulting in short telomeres in humans manifest as syndromes of precocious aging. In women, telomere length limits a fertilized egg's capacity to develop into a healthy embryo. Thus, telomere length must be reset with each subsequent generation. Although telomerase is purportedly responsible for restoring telomere DNA, recent studies have elucidated the role of alternative telomeres lengthening mechanisms in the reprogramming of early embryos and stem cells, which we review here. Hindawi Publishing Corporation 2014 2014-02-27 /pmc/articles/PMC3955682/ /pubmed/24719895 http://dx.doi.org/10.1155/2014/925121 Text en Copyright © 2014 Keri Kalmbach et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kalmbach, Keri
Robinson, LeRoy G.
Wang, Fang
Liu, Lin
Keefe, David
Telomere Length Reprogramming in Embryos and Stem Cells
title Telomere Length Reprogramming in Embryos and Stem Cells
title_full Telomere Length Reprogramming in Embryos and Stem Cells
title_fullStr Telomere Length Reprogramming in Embryos and Stem Cells
title_full_unstemmed Telomere Length Reprogramming in Embryos and Stem Cells
title_short Telomere Length Reprogramming in Embryos and Stem Cells
title_sort telomere length reprogramming in embryos and stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955682/
https://www.ncbi.nlm.nih.gov/pubmed/24719895
http://dx.doi.org/10.1155/2014/925121
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