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The Closely Related CD103(+) Dendritic Cells (DCs) and Lymphoid-Resident CD8(+) DCs Differ in Their Inflammatory Functions

Migratory CD103(+) and lymphoid-resident CD8(+) dendritic cells (DCs) share many attributes, such as dependence on the same transcription factors, cross-presenting ability and expression of certain surface molecules, such that it has been proposed they belong to a common sub-lineage. The functional...

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Detalles Bibliográficos
Autores principales: Jiao, Zhijun, Bedoui, Sammy, Brady, Jamie L., Walter, Anne, Chopin, Michael, Carrington, Emma M., Sutherland, Robyn M., Nutt, Stephen L., Zhang, Yuxia, Ko, Hyun-Ja, Wu, Li, Lew, Andrew M., Zhan, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956455/
https://www.ncbi.nlm.nih.gov/pubmed/24637385
http://dx.doi.org/10.1371/journal.pone.0091126
Descripción
Sumario:Migratory CD103(+) and lymphoid-resident CD8(+) dendritic cells (DCs) share many attributes, such as dependence on the same transcription factors, cross-presenting ability and expression of certain surface molecules, such that it has been proposed they belong to a common sub-lineage. The functional diversity of the two DC types is nevertheless incompletely understood. Here we reveal that upon skin infection with herpes simplex virus, migratory CD103(+) DCs from draining lymph nodes were more potent at inducing Th17 cytokine production by CD4(+) T cells than CD8(+) DCs. This superior capacity to drive Th17 responses was also evident in CD103(+) DCs from uninfected mice. Their differential potency to induce Th17 differentiation was reflected by higher production of IL-1β and IL-6 by CD103(+) DCs compared with CD8(+) DCs upon stimulation. The two types of DCs from isolated lymph nodes also differ in expression of certain pattern recognition receptors. Furthermore, elevated levels of GM-CSF, typical of those found in inflammation, substantially increased the pool size of CD103(+) DCs in lymph nodes and skin. We argue that varied levels of GM-CSF may explain the contrasting reports regarding the positive role of GM-CSF in regulating development of CD103(+) DCs. Together, we find that these two developmentally closely-related DC subsets display functional differences and that GM-CSF has differential effect on the two types of DCs.