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ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence
The maintenance of endoplasmic reticulum (ER) homeostasis is critical for numerous aspects of cell physiology. Eukaryotic cells respond to the accumulation of misfolded proteins in the ER (ER stress) by activating the unfolded protein response (UPR), an intracellular signaling pathway that adjusts t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956515/ https://www.ncbi.nlm.nih.gov/pubmed/24335436 http://dx.doi.org/10.4161/viru.27373 |
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author | Miyazaki, Taiga Kohno, Shigeru |
author_facet | Miyazaki, Taiga Kohno, Shigeru |
author_sort | Miyazaki, Taiga |
collection | PubMed |
description | The maintenance of endoplasmic reticulum (ER) homeostasis is critical for numerous aspects of cell physiology. Eukaryotic cells respond to the accumulation of misfolded proteins in the ER (ER stress) by activating the unfolded protein response (UPR), an intracellular signaling pathway that adjusts the folding capacity of the ER. Recent studies of several pathogenic fungi have revealed that the UPR is important for antifungal resistance and virulence; therefore, the pathway has attracted much attention as a potential therapeutic target. While the UPR is highly conserved among eukaryotes, our group recently discovered that the pathogenic yeast Candida glabrata lacks the typical fungal UPR, but possesses alternative mechanisms to cope with ER stress. This review summarizes how C. glabrata responds to ER stress and discusses the impacts of ER quality control systems on antifungal resistance and virulence. |
format | Online Article Text |
id | pubmed-3956515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-39565152014-03-24 ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence Miyazaki, Taiga Kohno, Shigeru Virulence Review The maintenance of endoplasmic reticulum (ER) homeostasis is critical for numerous aspects of cell physiology. Eukaryotic cells respond to the accumulation of misfolded proteins in the ER (ER stress) by activating the unfolded protein response (UPR), an intracellular signaling pathway that adjusts the folding capacity of the ER. Recent studies of several pathogenic fungi have revealed that the UPR is important for antifungal resistance and virulence; therefore, the pathway has attracted much attention as a potential therapeutic target. While the UPR is highly conserved among eukaryotes, our group recently discovered that the pathogenic yeast Candida glabrata lacks the typical fungal UPR, but possesses alternative mechanisms to cope with ER stress. This review summarizes how C. glabrata responds to ER stress and discusses the impacts of ER quality control systems on antifungal resistance and virulence. Landes Bioscience 2014-02-15 2013-12-11 /pmc/articles/PMC3956515/ /pubmed/24335436 http://dx.doi.org/10.4161/viru.27373 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Miyazaki, Taiga Kohno, Shigeru ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence |
title | ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence |
title_full | ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence |
title_fullStr | ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence |
title_full_unstemmed | ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence |
title_short | ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence |
title_sort | er stress response mechanisms in the pathogenic yeast candida glabrata and their roles in virulence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956515/ https://www.ncbi.nlm.nih.gov/pubmed/24335436 http://dx.doi.org/10.4161/viru.27373 |
work_keys_str_mv | AT miyazakitaiga erstressresponsemechanismsinthepathogenicyeastcandidaglabrataandtheirrolesinvirulence AT kohnoshigeru erstressresponsemechanismsinthepathogenicyeastcandidaglabrataandtheirrolesinvirulence |