Cargando…

HIV-1 Infected Peripheral Blood Mononuclear Cells Modulate the Fibrogenic Activity of Hepatic Stellate Cells through Secreted TGF-β and JNK Signaling

BACKGROUND AND AIMS: Patients with liver disease infected with the human immunodeficiency virus (HIV) exhibit accelerated progression of hepatic fibrosis and liver cirrhosis compared to uninfected individuals. We studied the effects of soluble factors secreted by HIV-infected peripheral blood mononu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Deepti, Rani, Manjusha, Khan, Nabab, Jameel, Shahid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956633/ https://www.ncbi.nlm.nih.gov/pubmed/24637780 http://dx.doi.org/10.1371/journal.pone.0091569

Ejemplares similares

The Expression of HIV-1 Vpu in Monocytes Causes Increased Secretion of TGF-β that Activates Profibrogenic Genes in Hepatic Stellate Cells
por: Patel, Paresh, et al.
Publicado: (2014)

Periostin down-regulation attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-β1
por: Hong, Li, et al.
Publicado: (2015)

Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells
por: Moran-Salvador, Eva, et al.
Publicado: (2019)

SerpinB3 Promotes Pro-fibrogenic Responses in Activated Hepatic Stellate Cells
por: Novo, Erica, et al.
Publicado: (2017)

Schistosoma japonicum Eggs Induce a Proinflammatory, Anti-Fibrogenic Phenotype in Hepatic Stellate Cells
por: Anthony, Barrie J., et al.
Publicado: (2013)

miR-185 Inhibits Fibrogenic Activation of Hepatic Stellate Cells and Prevents Liver Fibrosis
por: Zhou, Li, et al.
Publicado: (2017)

Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin
por: Gajendiran, Priya, et al.
Publicado: (2018)

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor
por: Minakshi, Rinki, et al.
Publicado: (2009)

TGF-β1-induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathways
por: Zhang, Jing, et al.
Publicado: (2021)

Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells
por: Koda, Masahiko, et al.
Publicado: (2006)

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy
por: Kim, Rosa S., et al.
Publicado: (2016)

TGF-β in developmental and fibrogenic EMTs
por: Lee, Jun Ho, et al.
Publicado: (2022)

Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System
por: Akil, Abdellah, et al.
Publicado: (2019)

Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells
por: Sigala, Barbara, et al.
Publicado: (2013)

Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase
por: Li, Zhen, et al.
Publicado: (2018)

Alpha-single chains of collagen type VI inhibit the fibrogenic effects of triple helical collagen VI in hepatic stellate cells
por: Freise, Christian, et al.
Publicado: (2021)

Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis
por: Kandhi, Rajani, et al.
Publicado: (2023)

Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling
por: Wu, Yinjuan, et al.
Publicado: (2017)

The P2X7 Receptor Supports Both Life and Death in Fibrogenic Pancreatic Stellate Cells
por: Haanes, Kristian A., et al.
Publicado: (2012)

Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice
por: Senoo, Takemasa, et al.
Publicado: (2018)

Hydrophobic Bile Salts Induce Pro-Fibrogenic Proliferation of Hepatic Stellate Cells through PI3K p110 Alpha Signaling
por: Zimny, Sebastian, et al.
Publicado: (2022)

Induction of premature senescence and a less-fibrogenic phenotype by programmed cell death 4 knockdown in the human hepatic stellate cell line Lieming Xu-2
por: Perveen, Rasheda, et al.
Publicado: (2022)

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
por: Dewidar, Bedair, et al.
Publicado: (2019)

Parkin-Mediated Mitophagy by TGF-β Is Connected with Hepatic Stellate Cell Activation
por: Lee, Ji Hyun, et al.
Publicado: (2023)

Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis
por: Kim, Byeong-Moo, et al.
Publicado: (2018)

Cytokine Secretion of Peripheral Blood Mononuclear Cells by Hydnocarpus anthelminthicus Seeds
por: Leelawat, Surang, et al.
Publicado: (2018)

12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells
por: Bao, Yunyang, et al.
Publicado: (2019)

Effect of Exogenous Fetuin-A on TGF-β/Smad Signaling in Hepatic Stellate Cells
por: Zhou, Yulai, et al.
Publicado: (2016)

Data on the effect of pro-fibrotic cytokine TGF-β on hepatic stellate cell autophagy
por: Thomes, Paul G., et al.
Publicado: (2016)

Antifibrotic effect of methylated quercetin derivatives on TGFβ-induced hepatic stellate cells
por: Ganbold, Munkhzul, et al.
Publicado: (2019)

TGF-β in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis
por: Panahipour, Layla, et al.
Publicado: (2020)

Effect of Interleukin-29 on Interferon-α Secretion by Peripheral Blood Mononuclear Cells
por: Cho, Chi Hyun, et al.
Publicado: (2015)

TRPV4 Channel Inhibits TGF-β1-Induced Proliferation of Hepatic Stellate Cells
por: Song, Yang, et al.
Publicado: (2014)

mTOR inhibitors potentially reduce TGF-β2-induced fibrogenic changes in trabecular meshwork cells
por: Igarashi, Nozomi, et al.
Publicado: (2021)

AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M
por: Tardelli, Matteo, et al.
Publicado: (2017)

TGF-β Signaling in Cancer: Control by Negative Regulators and Crosstalk with Proinflammatory and Fibrogenic Pathways
por: Ungefroren, Hendrik
Publicado: (2019)

TGF-β activates NLRP3 inflammasome by an autocrine production of TGF-β in LX-2 human hepatic stellate cells
por: Kang, Hwansu, et al.
Publicado: (2022)

Hepatic Stellate Cells and Hepatocarcinogenesis
por: Barry, Anna E., et al.
Publicado: (2020)

Hepatic Stellate Cells Secreted Hepatocyte Growth Factor Contributes to the Chemoresistance of Hepatocellular Carcinoma
por: Yu, Guofeng, et al.
Publicado: (2013)

Author Correction: Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis
por: Kim, Byeong-Moo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7nqmg8vs11uuoom6q5fboslasf