Coupling of a bifunctional peptide R13 to OTMCS-PEI copolymer as a gene vector increases transfection efficiency and tumor targeting

BACKGROUND: A degradable polyethylenimine (PEI) derivative coupled to a bifunctional peptide R13 was developed to solve the transfection efficiency versus cytotoxicity and tumor-targeting problems of PEI when used as a gene vector. METHODS: We crossed-linked low molecular weight PEI with N-octyl-N-q...

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Detalles Bibliográficos
Autores principales: Lv, Hui, Zhu, Qing, Liu, Kewu, Zhu, Manman, Zhao, Wenfang, Mao, Yuan, Liu, Kehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956686/
https://www.ncbi.nlm.nih.gov/pubmed/24648730
http://dx.doi.org/10.2147/IJN.S59726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956686/
https://www.ncbi.nlm.nih.gov/pubmed/24648730
http://dx.doi.org/10.2147/IJN.S59726

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