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Warfarin-Induced Skin Necrosis
Warfarin-induced skin necrosis is an infrequent complication occurring in individuals under warfarin treatment who have a thrombophilic history or after administration of large loading doses of warfarin particularly without simultaneous initial use of heparin. A 62-year-old lady developed skin necro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Dermatological Association; The Korean Society for Investigative Dermatology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956802/ https://www.ncbi.nlm.nih.gov/pubmed/24648693 http://dx.doi.org/10.5021/ad.2014.26.1.96 |
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author | Kakagia, Despoina D. Papanas, Nikolaos Karadimas, Efthimios Polychronidis, Alexandros |
author_facet | Kakagia, Despoina D. Papanas, Nikolaos Karadimas, Efthimios Polychronidis, Alexandros |
author_sort | Kakagia, Despoina D. |
collection | PubMed |
description | Warfarin-induced skin necrosis is an infrequent complication occurring in individuals under warfarin treatment who have a thrombophilic history or after administration of large loading doses of warfarin particularly without simultaneous initial use of heparin. A 62-year-old lady developed skin necrosis 4 days after initiating warfarin therapy of 5 mg daily without initial co-administration of heparin. The patient had a normal clotting profile. Skin necrosis progressed to eschar formation after cessation of warfarin and heparinization stopped expanding. Warfarin was reintroduced at 2 mg daily, initially together with low molecular weight heparin. Autolytic debridement of the necrotic tissue was followed by healing of the cutaneous deficit by secondary intention. Prompt diagnosis and discontinuation of warfarin are crucial for the prognosis. |
format | Online Article Text |
id | pubmed-3956802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-39568022014-03-19 Warfarin-Induced Skin Necrosis Kakagia, Despoina D. Papanas, Nikolaos Karadimas, Efthimios Polychronidis, Alexandros Ann Dermatol Case Report Warfarin-induced skin necrosis is an infrequent complication occurring in individuals under warfarin treatment who have a thrombophilic history or after administration of large loading doses of warfarin particularly without simultaneous initial use of heparin. A 62-year-old lady developed skin necrosis 4 days after initiating warfarin therapy of 5 mg daily without initial co-administration of heparin. The patient had a normal clotting profile. Skin necrosis progressed to eschar formation after cessation of warfarin and heparinization stopped expanding. Warfarin was reintroduced at 2 mg daily, initially together with low molecular weight heparin. Autolytic debridement of the necrotic tissue was followed by healing of the cutaneous deficit by secondary intention. Prompt diagnosis and discontinuation of warfarin are crucial for the prognosis. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2014-02 2014-02-17 /pmc/articles/PMC3956802/ /pubmed/24648693 http://dx.doi.org/10.5021/ad.2014.26.1.96 Text en Copyright © 2014 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kakagia, Despoina D. Papanas, Nikolaos Karadimas, Efthimios Polychronidis, Alexandros Warfarin-Induced Skin Necrosis |
title | Warfarin-Induced Skin Necrosis |
title_full | Warfarin-Induced Skin Necrosis |
title_fullStr | Warfarin-Induced Skin Necrosis |
title_full_unstemmed | Warfarin-Induced Skin Necrosis |
title_short | Warfarin-Induced Skin Necrosis |
title_sort | warfarin-induced skin necrosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956802/ https://www.ncbi.nlm.nih.gov/pubmed/24648693 http://dx.doi.org/10.5021/ad.2014.26.1.96 |
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