Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice

BLK, which encodes B lymphoid kinase, was recently identified in genome wide association studies as a susceptibility gene for systemic lupus erythematosus (SLE), and risk alleles mapping to the BLK locus result in reduced gene expression. To determine whether BLK is indeed a bona fide susceptibility...

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Detalles Bibliográficos
Autores principales: Samuelson, Elizabeth M., Laird, Renee M., Papillion, Amber M., Tatum, Arthur H., Princiotta, Michael F., Hayes, Sandra M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956874/
https://www.ncbi.nlm.nih.gov/pubmed/24637841
http://dx.doi.org/10.1371/journal.pone.0092054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956874/
https://www.ncbi.nlm.nih.gov/pubmed/24637841
http://dx.doi.org/10.1371/journal.pone.0092054

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