Cargando…

BikDDA, a Mutant of Bik with Longer Half-Life Expression Protein, Can Be a Novel Therapeutic Gene for Triple-Negative Breast Cancer

Our previous studies showed that BikDD, a constitutively active mutant form of Bik, exhibited powerful antitumor effects in preclinical pancreatic, lung and breast cancer models. Howerver, the antitumor activity of BikDD in triple-negative breast cancer (TNBC) is unknown. Here we show that aberrant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiao, Shiping, Wu, Minqing, Ye, Feng, Tang, Hailin, Xie, Xinhua, Xie, Xiaoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956915/ https://www.ncbi.nlm.nih.gov/pubmed/24637719 http://dx.doi.org/10.1371/journal.pone.0092172

Ejemplares similares

Arabidopsis Mutant bik1 Exhibits Strong Resistance to Plasmodiophora brassicae
por: Chen, Tao, et al.
Publicado: (2016)

Polyploids require Bik1 for kinetochore–microtubule attachment
por: Lin, Haijiang, et al.
Publicado: (2001)

Ligand-induced BIK1 monoubiquitination regulates plant immunity
por: Ma, Xiyu, et al.
Publicado: (2020)

Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs
por: Happo, L, et al.
Publicado: (2012)

Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis
por: Gillissen, Bernhard, et al.
Publicado: (2007)

The microtubule plus-end tracking protein Bik1 is required for chromosome congression
por: Julner, Alexander, et al.
Publicado: (2022)

Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins
por: Osterlund, Elizabeth J., et al.
Publicado: (2023)

Cancer Targeted Gene Therapy of BikDD Inhibits Orthotopic Lung Cancer Growth and Improves Long-term Survival
por: Sher, Yuh-Pyng, et al.
Publicado: (2009)

The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1
por: Couto, Daniel, et al.
Publicado: (2016)

Die and let live: harnessing BikDD to combat breast cancer stem cells
por: Giuliano, Mario, et al.
Publicado: (2012)

BIK1 and ERECTA Play Opposing Roles in Both Leaf and Inflorescence Development in Arabidopsis
por: Chen, Sufen, et al.
Publicado: (2019)

BIK1 protein homeostasis is maintained by the interplay of different ubiquitin ligases in immune signaling
por: Bai, Jiaojiao, et al.
Publicado: (2023)

The calcium-dependent protein kinase CPK28 negatively regulates the BIK1-mediated PAMP-induced calcium burst
por: Monaghan, Jacqueline, et al.
Publicado: (2015)

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
por: Mebratu, Yohannes A., et al.
Publicado: (2017)

BIK is a novel pro-apoptotic target gene for miR-125b in human monocytes
por: Duroux-Richard, I, et al.
Publicado: (2010)

Combination of lenalidomide with vitamin D3 induces apoptosis in mantle cell lymphoma via demethylation of BIK
por: Brosseau, C, et al.
Publicado: (2014)

Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice
por: Soni, Sourabh, et al.
Publicado: (2023)

Thermally-Induced Spin Crossover and LIESST Effect in the Neutral [Fe(II)((Me)bik)(2)(NCX)(2)] Complexes: Variable-Temperature Structural, Magnetic, and Optical Studies (X = S, Se; (Me)bik = bis(1-methylimidazol-2-yl)ketone)
por: De, Siddhartha, et al.
Publicado: (2018)

BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin
Publicado: (1990)

TGF-β induces apoptosis in human B cells via transcriptional regulation of BIK and BCL-X(L)
por: Spender, LC, et al.
Publicado: (2009)

BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma
por: Bodet, L, et al.
Publicado: (2010)

Suppression of the death gene BIK is a critical factor for resistance to tamoxifen in MCF-7 breast cancer cells
por: VIEDMA-RODRIGUEZ, RUBÍ, et al.
Publicado: (2013)

MicroRNA 486-3p directly targets BIK and regulates apoptosis and invasion in colorectal cancer cells
por: Feng, Li, et al.
Publicado: (2018)

Comparing Arabidopsis receptor kinase and receptor protein‐mediated immune signaling reveals BIK1‐dependent differences
por: Wan, Wei‐Lin, et al.
Publicado: (2018)

Correction: Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice
por: Soni, Sourabh, et al.
Publicado: (2023)

p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress
por: López, Ignacio, et al.
Publicado: (2017)

BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress
por: Chen, Fei-Yun, et al.
Publicado: (2019)

Plumbagin sensitizes breast cancer cells to tamoxifen-induced cell death through GRP78 inhibition and Bik upregulation
por: Kawiak, Anna, et al.
Publicado: (2017)

A molecular analysis by gene expression profiling reveals Bik/NBK overexpression in sporadic breast tumor samples of Mexican females
por: García, Normand, et al.
Publicado: (2005)

Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma
por: Dai, Huei-Yue, et al.
Publicado: (2015)

Microbe-associated molecular pattern-induced calcium signaling requires the receptor-like cytoplasmic kinases, PBL1 and BIK1
por: Ranf, Stefanie, et al.
Publicado: (2014)

The Arabidopsis Cysteine-Rich Receptor-Like Kinase CRK36 Regulates Immunity through Interaction with the Cytoplasmic Kinase BIK1
por: Lee, Dong Sook, et al.
Publicado: (2017)

Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells
por: Kutuk, Ozgur, et al.
Publicado: (2017)

BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer
por: Pandya, Vrajesh, et al.
Publicado: (2020)

HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway
por: Spaety, Marie-Elodie, et al.
Publicado: (2019)

The PTI‐suppressing Avr2 effector from Fusarium oxysporum suppresses mono‐ubiquitination and plasma membrane dissociation of BIK1
por: Blekemolen, Mila C., et al.
Publicado: (2023)

The pro-apoptotic paradox: the BH3-only protein Bcl-2 interacting killer (Bik) is prognostic for unfavorable outcomes in breast cancer
por: Pandya, Vrajesh, et al.
Publicado: (2016)

Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells
por: Xi, Yue, et al.
Publicado: (2015)

A role for the yeast CLIP170 ortholog, the plus-end-tracking protein Bik1, and the Rho1 GTPase in Snc1 trafficking
por: Boscheron, Cécile, et al.
Publicado: (2016)

LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK
por: Si, Xinxin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_63e5gsr7d78t1argsq67btksp7