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Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts

PURPOSE: To evaluate the prevalence and type distribution of high-risk human papillomavirus (HPV) infection in genital warts of Korean men, and for the first time, to describe the risk factors associated with high-risk HPV infection in male genital warts. MATERIALS AND METHODS: In a single private c...

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Autores principales: Park, Sung Jin, Seo, Juhyung, Ha, Seong-Heon, Jung, Gyung-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956951/
https://www.ncbi.nlm.nih.gov/pubmed/24648877
http://dx.doi.org/10.4111/kju.2014.55.3.207
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author Park, Sung Jin
Seo, Juhyung
Ha, Seong-Heon
Jung, Gyung-Woo
author_facet Park, Sung Jin
Seo, Juhyung
Ha, Seong-Heon
Jung, Gyung-Woo
author_sort Park, Sung Jin
collection PubMed
description PURPOSE: To evaluate the prevalence and type distribution of high-risk human papillomavirus (HPV) infection in genital warts of Korean men, and for the first time, to describe the risk factors associated with high-risk HPV infection in male genital warts. MATERIALS AND METHODS: In a single private clinic, 150 consecutive male patients with histopathologic-confirmed genital warts who underwent HPV genotyping by use of polymerase chain reaction (PCR) were included in this study. We detected HPV DNA in male genital warts and evaluated HPV type distribution, especially high-risk HPV types, by use of PCR. The associations between HPV prevalence and various characteristics, such as age, circumcision status, type of genital warts diagnosis (new vs. recurrent), number of lesions, site of lesions, and gross morphology, were assessed by use of unconditional multiple logistic regression. RESULTS: High-risk HPV types were detected in 31 cases (23.5%), and of these, 27 cases (20.5%) contained both high-risk and low-risk HPV types. The most frequently detected high-risk HPV types were HPV16 (6.8%), HPV33 (4.5%), HPV18 (2.3%), and HPV68 (2.3%). In particular, the prevalence of infection with HPV16 and/or HPV18 was 8.3% (11 of 132). In the multivariate analysis, lesions located at sites including the base of the penis or the pubic area, papular or mixed genital warts, and lack of circumcision significantly increased the association with high-risk HPV infection in male genital warts. CONCLUSIONS: The prevalence of high-risk HPV infection was substantial in male genital warts. The site and morphology of lesions and circumcision status were significantly associated with the prevalence of high-risk HPV infection.
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spelling pubmed-39569512014-03-19 Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts Park, Sung Jin Seo, Juhyung Ha, Seong-Heon Jung, Gyung-Woo Korean J Urol Original Article PURPOSE: To evaluate the prevalence and type distribution of high-risk human papillomavirus (HPV) infection in genital warts of Korean men, and for the first time, to describe the risk factors associated with high-risk HPV infection in male genital warts. MATERIALS AND METHODS: In a single private clinic, 150 consecutive male patients with histopathologic-confirmed genital warts who underwent HPV genotyping by use of polymerase chain reaction (PCR) were included in this study. We detected HPV DNA in male genital warts and evaluated HPV type distribution, especially high-risk HPV types, by use of PCR. The associations between HPV prevalence and various characteristics, such as age, circumcision status, type of genital warts diagnosis (new vs. recurrent), number of lesions, site of lesions, and gross morphology, were assessed by use of unconditional multiple logistic regression. RESULTS: High-risk HPV types were detected in 31 cases (23.5%), and of these, 27 cases (20.5%) contained both high-risk and low-risk HPV types. The most frequently detected high-risk HPV types were HPV16 (6.8%), HPV33 (4.5%), HPV18 (2.3%), and HPV68 (2.3%). In particular, the prevalence of infection with HPV16 and/or HPV18 was 8.3% (11 of 132). In the multivariate analysis, lesions located at sites including the base of the penis or the pubic area, papular or mixed genital warts, and lack of circumcision significantly increased the association with high-risk HPV infection in male genital warts. CONCLUSIONS: The prevalence of high-risk HPV infection was substantial in male genital warts. The site and morphology of lesions and circumcision status were significantly associated with the prevalence of high-risk HPV infection. The Korean Urological Association 2014-03 2014-03-13 /pmc/articles/PMC3956951/ /pubmed/24648877 http://dx.doi.org/10.4111/kju.2014.55.3.207 Text en © The Korean Urological Association, 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Sung Jin
Seo, Juhyung
Ha, Seong-Heon
Jung, Gyung-Woo
Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts
title Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts
title_full Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts
title_fullStr Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts
title_full_unstemmed Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts
title_short Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts
title_sort prevalence and determinants of high-risk human papillomavirus infection in male genital warts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956951/
https://www.ncbi.nlm.nih.gov/pubmed/24648877
http://dx.doi.org/10.4111/kju.2014.55.3.207
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