New Taxane Diterpenoids from Taxus yunnanensis

Three hitherto unknown taxane diterpenoids, namely baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analys...

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Detalles Bibliográficos
Autores principales: Hai, Ping, Wen, Shi-Zhen, Li, Yan, Gao, Yuan, Jiang, Xian-Jun, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956972/
https://www.ncbi.nlm.nih.gov/pubmed/24660136
http://dx.doi.org/10.1007/s13659-014-0003-9
Descripción
Sumario:Three hitherto unknown taxane diterpenoids, namely baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC(50) values of 3.44 and 9.67 μM, respectively. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0003-9) contains supplementary material, which is available to authorized users.

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