New Taxane Diterpenoids from Taxus yunnanensis

Three hitherto unknown taxane diterpenoids, namely baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analys...

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Detalles Bibliográficos
Autores principales: Hai, Ping, Wen, Shi-Zhen, Li, Yan, Gao, Yuan, Jiang, Xian-Jun, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956972/
https://www.ncbi.nlm.nih.gov/pubmed/24660136
http://dx.doi.org/10.1007/s13659-014-0003-9
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author Hai, Ping
Wen, Shi-Zhen
Li, Yan
Gao, Yuan
Jiang, Xian-Jun
Wang, Fei
author_facet Hai, Ping
Wen, Shi-Zhen
Li, Yan
Gao, Yuan
Jiang, Xian-Jun
Wang, Fei
author_sort Hai, Ping
collection PubMed
description Three hitherto unknown taxane diterpenoids, namely baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC(50) values of 3.44 and 9.67 μM, respectively. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0003-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-39569722014-03-21 New Taxane Diterpenoids from Taxus yunnanensis Hai, Ping Wen, Shi-Zhen Li, Yan Gao, Yuan Jiang, Xian-Jun Wang, Fei Nat Prod Bioprospect Original Article Three hitherto unknown taxane diterpenoids, namely baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC(50) values of 3.44 and 9.67 μM, respectively. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0003-9) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-02-19 /pmc/articles/PMC3956972/ /pubmed/24660136 http://dx.doi.org/10.1007/s13659-014-0003-9 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/2.0/ This article is published under license to BioMed Central Ltd. Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Hai, Ping
Wen, Shi-Zhen
Li, Yan
Gao, Yuan
Jiang, Xian-Jun
Wang, Fei
New Taxane Diterpenoids from Taxus yunnanensis
title New Taxane Diterpenoids from Taxus yunnanensis
title_full New Taxane Diterpenoids from Taxus yunnanensis
title_fullStr New Taxane Diterpenoids from Taxus yunnanensis
title_full_unstemmed New Taxane Diterpenoids from Taxus yunnanensis
title_short New Taxane Diterpenoids from Taxus yunnanensis
title_sort new taxane diterpenoids from taxus yunnanensis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956972/
https://www.ncbi.nlm.nih.gov/pubmed/24660136
http://dx.doi.org/10.1007/s13659-014-0003-9
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