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Whole blood versus serum ionized calcium concentrations in dialysis patients
BACKGROUND/AIMS: The aim of this study is to measure the difference of ionized calcium between heparinized whole blood and serum. METHODS: We recruited 107 maintenance hemodialysis (HD) patients from our hospital HD unit. The clinical and laboratory data included ionized calcium in serum and in whol...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956993/ https://www.ncbi.nlm.nih.gov/pubmed/24648806 http://dx.doi.org/10.3904/kjim.2014.29.2.226 |
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author | Kang, Seok Hui Cho, Kyu Hyang Park, Jong Won Yoon, Kyung Woo Do, Jun Young |
author_facet | Kang, Seok Hui Cho, Kyu Hyang Park, Jong Won Yoon, Kyung Woo Do, Jun Young |
author_sort | Kang, Seok Hui |
collection | PubMed |
description | BACKGROUND/AIMS: The aim of this study is to measure the difference of ionized calcium between heparinized whole blood and serum. METHODS: We recruited 107 maintenance hemodialysis (HD) patients from our hospital HD unit. The clinical and laboratory data included ionized calcium in serum and in whole blood (reference, 4.07 to 5.17 mg/dL). RESULTS: The level of ionized calcium in serum was higher than that in whole blood (p < 0.001). Bland-Altman analysis showed that difference for ionized calcium was 0.5027. For the difference, the nonstandardized β was -0.4389 (p < 0.001) and the intercept was 2.2418 (p < 0.001). There was a significant difference in the distribution of categories of ionized calcium level between two methods (κ, 0.279; p < 0.001). CONCLUSIONS: This study demonstrates that whole blood ionized calcium is underestimated compared with serum ionized calcium. Positive difference increases as whole blood ionized calcium decreases. Therefore, significant hypocalcemia in whole blood ionized calcium should be verified by serum ionized calcium. |
format | Online Article Text |
id | pubmed-3956993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-39569932014-03-19 Whole blood versus serum ionized calcium concentrations in dialysis patients Kang, Seok Hui Cho, Kyu Hyang Park, Jong Won Yoon, Kyung Woo Do, Jun Young Korean J Intern Med Original Article BACKGROUND/AIMS: The aim of this study is to measure the difference of ionized calcium between heparinized whole blood and serum. METHODS: We recruited 107 maintenance hemodialysis (HD) patients from our hospital HD unit. The clinical and laboratory data included ionized calcium in serum and in whole blood (reference, 4.07 to 5.17 mg/dL). RESULTS: The level of ionized calcium in serum was higher than that in whole blood (p < 0.001). Bland-Altman analysis showed that difference for ionized calcium was 0.5027. For the difference, the nonstandardized β was -0.4389 (p < 0.001) and the intercept was 2.2418 (p < 0.001). There was a significant difference in the distribution of categories of ionized calcium level between two methods (κ, 0.279; p < 0.001). CONCLUSIONS: This study demonstrates that whole blood ionized calcium is underestimated compared with serum ionized calcium. Positive difference increases as whole blood ionized calcium decreases. Therefore, significant hypocalcemia in whole blood ionized calcium should be verified by serum ionized calcium. The Korean Association of Internal Medicine 2014-03 2014-02-27 /pmc/articles/PMC3956993/ /pubmed/24648806 http://dx.doi.org/10.3904/kjim.2014.29.2.226 Text en Copyright © 2014 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kang, Seok Hui Cho, Kyu Hyang Park, Jong Won Yoon, Kyung Woo Do, Jun Young Whole blood versus serum ionized calcium concentrations in dialysis patients |
title | Whole blood versus serum ionized calcium concentrations in dialysis patients |
title_full | Whole blood versus serum ionized calcium concentrations in dialysis patients |
title_fullStr | Whole blood versus serum ionized calcium concentrations in dialysis patients |
title_full_unstemmed | Whole blood versus serum ionized calcium concentrations in dialysis patients |
title_short | Whole blood versus serum ionized calcium concentrations in dialysis patients |
title_sort | whole blood versus serum ionized calcium concentrations in dialysis patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956993/ https://www.ncbi.nlm.nih.gov/pubmed/24648806 http://dx.doi.org/10.3904/kjim.2014.29.2.226 |
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