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The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review

The identification of aflatoxins as human carcinogens has stimulated extensive research efforts, which continue to the present, to assess potential health hazards resulting from contamination of the human food supply and to minimize exposure. The use of biomarkers that are mechanistically supported...

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Autores principales: Valencia-Quintana, Rafael, Sánchez-Alarcón, Juana, Tenorio-Arvide, María G., Deng, Youjun, Montiel-González, José M. R., Gómez-Arroyo, Sandra, Villalobos-Pietrini, Rafael, Cortés-Eslava, Josefina, Flores-Márquez, Ana R., Arenas-Huertero, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957091/
https://www.ncbi.nlm.nih.gov/pubmed/24672518
http://dx.doi.org/10.3389/fmicb.2014.00102
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author Valencia-Quintana, Rafael
Sánchez-Alarcón, Juana
Tenorio-Arvide, María G.
Deng, Youjun
Montiel-González, José M. R.
Gómez-Arroyo, Sandra
Villalobos-Pietrini, Rafael
Cortés-Eslava, Josefina
Flores-Márquez, Ana R.
Arenas-Huertero, Francisco
author_facet Valencia-Quintana, Rafael
Sánchez-Alarcón, Juana
Tenorio-Arvide, María G.
Deng, Youjun
Montiel-González, José M. R.
Gómez-Arroyo, Sandra
Villalobos-Pietrini, Rafael
Cortés-Eslava, Josefina
Flores-Márquez, Ana R.
Arenas-Huertero, Francisco
author_sort Valencia-Quintana, Rafael
collection PubMed
description The identification of aflatoxins as human carcinogens has stimulated extensive research efforts, which continue to the present, to assess potential health hazards resulting from contamination of the human food supply and to minimize exposure. The use of biomarkers that are mechanistically supported by toxicological studies will be important tools for identifying stages in the progression of development of the health effects of environmental agents. miRNAs are small non-coding mRNAs that regulate post-transcriptional gene expression. Also, they are molecular markers of cellular responses to various chemical agents. Growing evidence has demonstrated that environmental chemicals can induce changes in miRNA expression. miRNAs are good biomarkers because they are well defined, chemically uniform, restricted to a manageable number of species, and stable in cells and in the circulation. miRNAs have been used as serological markers of HCC and other tumors. The expression patterns of different miRNAs can distinguish among HCC-hepatitis viruses related, HCC cirrhosis-derivate, and HCC unrelated to either of them. The main objective of this review is to find unreported miRNAs in HCC related to other causes, so that they can be used as specific molecular biomarkers in populations exposed to aflatoxins and as early markers of exposure, damage/presence of HCC. Until today specific miRNAs as markers for aflatoxins-exposure and their reliability are currently lacking. Based on their elucidated mechanisms of action, potential miRNAs that could serve as possible markers of HCC by exposure to aflatoxins are miR-27a, miR-27b, miR-122, miR-148, miR-155, miR-192, miR-214, miR-221, miR-429, and miR-500. Future validation for all of these miRNAs will be needed to assess their prognostic significance and confirm their relationship with the induction of HCC due to aflatoxin exposure.
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spelling pubmed-39570912014-03-26 The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review Valencia-Quintana, Rafael Sánchez-Alarcón, Juana Tenorio-Arvide, María G. Deng, Youjun Montiel-González, José M. R. Gómez-Arroyo, Sandra Villalobos-Pietrini, Rafael Cortés-Eslava, Josefina Flores-Márquez, Ana R. Arenas-Huertero, Francisco Front Microbiol Microbiology The identification of aflatoxins as human carcinogens has stimulated extensive research efforts, which continue to the present, to assess potential health hazards resulting from contamination of the human food supply and to minimize exposure. The use of biomarkers that are mechanistically supported by toxicological studies will be important tools for identifying stages in the progression of development of the health effects of environmental agents. miRNAs are small non-coding mRNAs that regulate post-transcriptional gene expression. Also, they are molecular markers of cellular responses to various chemical agents. Growing evidence has demonstrated that environmental chemicals can induce changes in miRNA expression. miRNAs are good biomarkers because they are well defined, chemically uniform, restricted to a manageable number of species, and stable in cells and in the circulation. miRNAs have been used as serological markers of HCC and other tumors. The expression patterns of different miRNAs can distinguish among HCC-hepatitis viruses related, HCC cirrhosis-derivate, and HCC unrelated to either of them. The main objective of this review is to find unreported miRNAs in HCC related to other causes, so that they can be used as specific molecular biomarkers in populations exposed to aflatoxins and as early markers of exposure, damage/presence of HCC. Until today specific miRNAs as markers for aflatoxins-exposure and their reliability are currently lacking. Based on their elucidated mechanisms of action, potential miRNAs that could serve as possible markers of HCC by exposure to aflatoxins are miR-27a, miR-27b, miR-122, miR-148, miR-155, miR-192, miR-214, miR-221, miR-429, and miR-500. Future validation for all of these miRNAs will be needed to assess their prognostic significance and confirm their relationship with the induction of HCC due to aflatoxin exposure. Frontiers Media S.A. 2014-03-18 /pmc/articles/PMC3957091/ /pubmed/24672518 http://dx.doi.org/10.3389/fmicb.2014.00102 Text en Copyright © 2014 Valencia-Quintana, Sánchez-Alarcón, Tenorio-Arvide, Deng, Montiel-González, Gómez-Arroyo, Villalobos-Pietrini, Cortés-Eslava, Flores-Márquez and Arenas-Huertero. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Valencia-Quintana, Rafael
Sánchez-Alarcón, Juana
Tenorio-Arvide, María G.
Deng, Youjun
Montiel-González, José M. R.
Gómez-Arroyo, Sandra
Villalobos-Pietrini, Rafael
Cortés-Eslava, Josefina
Flores-Márquez, Ana R.
Arenas-Huertero, Francisco
The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review
title The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review
title_full The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review
title_fullStr The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review
title_full_unstemmed The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review
title_short The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review
title_sort micrornas as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957091/
https://www.ncbi.nlm.nih.gov/pubmed/24672518
http://dx.doi.org/10.3389/fmicb.2014.00102
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