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Toxicity Evaluation of Microemulsion (Nano Size) of Sour Cherry Kernel Extract for the Oral Bioavailability Enhancement
BACKGROUND: In the recent years nanostructured materials have been the focus of researches due to their wide-spread possibilities to provide new shapes and structures for some materials. Microemulsions can provide uniform nano-sized droplets for templating. Microemulsions are isotropic, thermodynami...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
DOCS
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957138/ https://www.ncbi.nlm.nih.gov/pubmed/24644434 |
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author | Salimi, Anayatollah Motaharitabar, Eisa Goudarzi, Mehdi Rezaie, Annahita Kalantari, Heibatullah |
author_facet | Salimi, Anayatollah Motaharitabar, Eisa Goudarzi, Mehdi Rezaie, Annahita Kalantari, Heibatullah |
author_sort | Salimi, Anayatollah |
collection | PubMed |
description | BACKGROUND: In the recent years nanostructured materials have been the focus of researches due to their wide-spread possibilities to provide new shapes and structures for some materials. Microemulsions can provide uniform nano-sized droplets for templating. Microemulsions are isotropic, thermodynamically-stable systems of oil, water and surfactant with a 20-200 nm droplet size. They can be prepared as oil-in-water (o/w), water-in-oil (w/o) or bicontinuous systems, depending on the equilibrium spontaneous curvature of the surfactant layer at the oil-water interface. OBJECTIVES: The aim of this study was to introduce a system designed to improve and enhance the bioavailability of bioflavonoids in the Prunus cerasus (sour cherry) seed kernel extract by developing a novel delivery system, i.e. microemulsion (nanosized particles). MATERIALS AND METHODS: Microemulsion formulations were prepared by mixing appropriate amounts of surfactants (Tween 80 and Span 20), cosurfactant (propylene glycol) (3:1 ratio), and oil phase (olive oil). The prepared microemulsions were evaluated regarding their mean droplet size, transparency, viscosity, and pH. Sour cherry kernel extract microemulsion was orally administered to mice at doses of 2.5%, 5%, and 10% for 10 days. On the last day, their blood as well as their liver and kidney were used for biochemical and histopathological analyses, respectively. RESULTS: Biochemical factors levels and the pathological study indicated that there were not significant differences in microemulsion extracts compared with the control group (P > 0.05). CONCLUSIONS: Not only no toxicity evidence of this product was observed in the dose range used in foods or healthcare, but also it improved the cardiac function recovery. |
format | Online Article Text |
id | pubmed-3957138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | DOCS |
record_format | MEDLINE/PubMed |
spelling | pubmed-39571382014-03-18 Toxicity Evaluation of Microemulsion (Nano Size) of Sour Cherry Kernel Extract for the Oral Bioavailability Enhancement Salimi, Anayatollah Motaharitabar, Eisa Goudarzi, Mehdi Rezaie, Annahita Kalantari, Heibatullah Jundishapur J Nat Pharm Prod Research Article BACKGROUND: In the recent years nanostructured materials have been the focus of researches due to their wide-spread possibilities to provide new shapes and structures for some materials. Microemulsions can provide uniform nano-sized droplets for templating. Microemulsions are isotropic, thermodynamically-stable systems of oil, water and surfactant with a 20-200 nm droplet size. They can be prepared as oil-in-water (o/w), water-in-oil (w/o) or bicontinuous systems, depending on the equilibrium spontaneous curvature of the surfactant layer at the oil-water interface. OBJECTIVES: The aim of this study was to introduce a system designed to improve and enhance the bioavailability of bioflavonoids in the Prunus cerasus (sour cherry) seed kernel extract by developing a novel delivery system, i.e. microemulsion (nanosized particles). MATERIALS AND METHODS: Microemulsion formulations were prepared by mixing appropriate amounts of surfactants (Tween 80 and Span 20), cosurfactant (propylene glycol) (3:1 ratio), and oil phase (olive oil). The prepared microemulsions were evaluated regarding their mean droplet size, transparency, viscosity, and pH. Sour cherry kernel extract microemulsion was orally administered to mice at doses of 2.5%, 5%, and 10% for 10 days. On the last day, their blood as well as their liver and kidney were used for biochemical and histopathological analyses, respectively. RESULTS: Biochemical factors levels and the pathological study indicated that there were not significant differences in microemulsion extracts compared with the control group (P > 0.05). CONCLUSIONS: Not only no toxicity evidence of this product was observed in the dose range used in foods or healthcare, but also it improved the cardiac function recovery. DOCS 2014-02-20 2014-02 /pmc/articles/PMC3957138/ /pubmed/24644434 Text en Copyright © 2014, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences; Published by DOCS. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Salimi, Anayatollah Motaharitabar, Eisa Goudarzi, Mehdi Rezaie, Annahita Kalantari, Heibatullah Toxicity Evaluation of Microemulsion (Nano Size) of Sour Cherry Kernel Extract for the Oral Bioavailability Enhancement |
title | Toxicity Evaluation of Microemulsion (Nano Size) of Sour Cherry Kernel Extract for the Oral Bioavailability Enhancement |
title_full | Toxicity Evaluation of Microemulsion (Nano Size) of Sour Cherry Kernel Extract for the Oral Bioavailability Enhancement |
title_fullStr | Toxicity Evaluation of Microemulsion (Nano Size) of Sour Cherry Kernel Extract for the Oral Bioavailability Enhancement |
title_full_unstemmed | Toxicity Evaluation of Microemulsion (Nano Size) of Sour Cherry Kernel Extract for the Oral Bioavailability Enhancement |
title_short | Toxicity Evaluation of Microemulsion (Nano Size) of Sour Cherry Kernel Extract for the Oral Bioavailability Enhancement |
title_sort | toxicity evaluation of microemulsion (nano size) of sour cherry kernel extract for the oral bioavailability enhancement |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957138/ https://www.ncbi.nlm.nih.gov/pubmed/24644434 |
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