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Long-Term Outcome of Vagus Nerve Stimulation for Refractory Epilepsy: A Longitudinal 4 year Follow-up Study in Korea

BACKGROUND AND PURPOSE: We evaluated the long-term outcome of patients with refractory epilepsy who were treated with vagus nerve stimulation (VNS). METHODS: This investigation is designed as an uncontrolled, open-label, retrospective and long-term study. From June 1999 to October 2009, 20 patients...

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Autores principales: Choi, Su Jung, Hong, Seung Chyul, Seo, Dae-Won, Joo, Eun Yeon, Cho, Jounhong Ryan, Hwang, Kyoung Jin, Kim, Ji Young, Hong, Seung Bong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Epilepsy Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957311/
https://www.ncbi.nlm.nih.gov/pubmed/24649466
http://dx.doi.org/10.14581/jer.13003
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author Choi, Su Jung
Hong, Seung Chyul
Seo, Dae-Won
Joo, Eun Yeon
Cho, Jounhong Ryan
Hwang, Kyoung Jin
Kim, Ji Young
Hong, Seung Bong
author_facet Choi, Su Jung
Hong, Seung Chyul
Seo, Dae-Won
Joo, Eun Yeon
Cho, Jounhong Ryan
Hwang, Kyoung Jin
Kim, Ji Young
Hong, Seung Bong
author_sort Choi, Su Jung
collection PubMed
description BACKGROUND AND PURPOSE: We evaluated the long-term outcome of patients with refractory epilepsy who were treated with vagus nerve stimulation (VNS). METHODS: This investigation is designed as an uncontrolled, open-label, retrospective and long-term study. From June 1999 to October 2009, 20 patients were suitable for inclusion criteria: 4-year follow-up and documented seizure frequency before and after implantation. Seizure frequency was collected by clinical recording and interview. Primary outcome measures were the reduction in mean seizure frequency and responder rate (seizure frequency reduction of >50%). RESULTS: In 20 patients (M:F=16:4), mean age at the time of implantation was 22.3 years (range 8–44) and mean disease duration was 13.9 years (range 1–37). Mean maximum stimulation output current was 1.90 mA (range 0.25–3.5). Overall mean seizure frequency reduction rate was 61.8% at 4 year follow-up comparison with baseline (p<0.001). Proposition of responder (> 50% seizure frequency reduction) of yearly follow-up were 40 % at 1 yr, 50% at 2 yrs, 45% at 3 yrs, and 60% at 4 yrs. There was no difference of stimulation parameter between the responders and non-responders. CONCLUSIONS: Long-term outcome of VNS suggests that VNS is an effective treatment option that can be alternative to surgery in patients with refractory epilepsy.
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spelling pubmed-39573112014-03-19 Long-Term Outcome of Vagus Nerve Stimulation for Refractory Epilepsy: A Longitudinal 4 year Follow-up Study in Korea Choi, Su Jung Hong, Seung Chyul Seo, Dae-Won Joo, Eun Yeon Cho, Jounhong Ryan Hwang, Kyoung Jin Kim, Ji Young Hong, Seung Bong J Epilepsy Res Original Article BACKGROUND AND PURPOSE: We evaluated the long-term outcome of patients with refractory epilepsy who were treated with vagus nerve stimulation (VNS). METHODS: This investigation is designed as an uncontrolled, open-label, retrospective and long-term study. From June 1999 to October 2009, 20 patients were suitable for inclusion criteria: 4-year follow-up and documented seizure frequency before and after implantation. Seizure frequency was collected by clinical recording and interview. Primary outcome measures were the reduction in mean seizure frequency and responder rate (seizure frequency reduction of >50%). RESULTS: In 20 patients (M:F=16:4), mean age at the time of implantation was 22.3 years (range 8–44) and mean disease duration was 13.9 years (range 1–37). Mean maximum stimulation output current was 1.90 mA (range 0.25–3.5). Overall mean seizure frequency reduction rate was 61.8% at 4 year follow-up comparison with baseline (p<0.001). Proposition of responder (> 50% seizure frequency reduction) of yearly follow-up were 40 % at 1 yr, 50% at 2 yrs, 45% at 3 yrs, and 60% at 4 yrs. There was no difference of stimulation parameter between the responders and non-responders. CONCLUSIONS: Long-term outcome of VNS suggests that VNS is an effective treatment option that can be alternative to surgery in patients with refractory epilepsy. Korean Epilepsy Society 2013-06-30 /pmc/articles/PMC3957311/ /pubmed/24649466 http://dx.doi.org/10.14581/jer.13003 Text en Copyright © 2013 Korean Epilepsy Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Su Jung
Hong, Seung Chyul
Seo, Dae-Won
Joo, Eun Yeon
Cho, Jounhong Ryan
Hwang, Kyoung Jin
Kim, Ji Young
Hong, Seung Bong
Long-Term Outcome of Vagus Nerve Stimulation for Refractory Epilepsy: A Longitudinal 4 year Follow-up Study in Korea
title Long-Term Outcome of Vagus Nerve Stimulation for Refractory Epilepsy: A Longitudinal 4 year Follow-up Study in Korea
title_full Long-Term Outcome of Vagus Nerve Stimulation for Refractory Epilepsy: A Longitudinal 4 year Follow-up Study in Korea
title_fullStr Long-Term Outcome of Vagus Nerve Stimulation for Refractory Epilepsy: A Longitudinal 4 year Follow-up Study in Korea
title_full_unstemmed Long-Term Outcome of Vagus Nerve Stimulation for Refractory Epilepsy: A Longitudinal 4 year Follow-up Study in Korea
title_short Long-Term Outcome of Vagus Nerve Stimulation for Refractory Epilepsy: A Longitudinal 4 year Follow-up Study in Korea
title_sort long-term outcome of vagus nerve stimulation for refractory epilepsy: a longitudinal 4 year follow-up study in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957311/
https://www.ncbi.nlm.nih.gov/pubmed/24649466
http://dx.doi.org/10.14581/jer.13003
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