Ink4a/Arf(−/−) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(−) quiescent cells

Intratumoral heterogeneity within individual breast tumors is a well-known phenomenon that may contribute to drug resistance. This heterogeneity is dependent on several factors, such as types of oncogenic drivers and tumor precursor cells. The purpose of our study was to engineer a mouse mammary tum...

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Detalles Bibliográficos
Autores principales: Kai, Kazuharu, Iwamoto, Takayuki, Kobayashi, Takashi, Arima, Yoshimi, Takamoto, Yayoi, Ohnishi, Nobuyuki, Bartholomeusz, Chandra, Horii, Rie, Akiyama, Futoshi, Hortobagyi, Gabriel N, Pusztai, Lajos, Saya, Hideyuki, Ueno, Naoto T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957346/
https://www.ncbi.nlm.nih.gov/pubmed/23376849
http://dx.doi.org/10.1038/onc.2012.609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957346/
https://www.ncbi.nlm.nih.gov/pubmed/23376849
http://dx.doi.org/10.1038/onc.2012.609

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