Transcription-coupled mutagenesis by the DNA deaminase AID

Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.

Detalles Bibliográficos
Autores principales: Larson, Erik D, Maizels, Nancy
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395756/
https://www.ncbi.nlm.nih.gov/pubmed/15003109
Descripción
Sumario:Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.

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