Transcription-coupled mutagenesis by the DNA deaminase AID

Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.

Detalles Bibliográficos
Autores principales: Larson, Erik D, Maizels, Nancy
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395756/
https://www.ncbi.nlm.nih.gov/pubmed/15003109
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author Larson, Erik D
Maizels, Nancy
author_facet Larson, Erik D
Maizels, Nancy
author_sort Larson, Erik D
collection PubMed
description Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.
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spelling pubmed-3957562004-04-24 Transcription-coupled mutagenesis by the DNA deaminase AID Larson, Erik D Maizels, Nancy Genome Biol Minireview Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA. BioMed Central 2004 2004-02-27 /pmc/articles/PMC395756/ /pubmed/15003109 Text en Copyright © 2004 BioMed Central Ltd
spellingShingle Minireview
Larson, Erik D
Maizels, Nancy
Transcription-coupled mutagenesis by the DNA deaminase AID
title Transcription-coupled mutagenesis by the DNA deaminase AID
title_full Transcription-coupled mutagenesis by the DNA deaminase AID
title_fullStr Transcription-coupled mutagenesis by the DNA deaminase AID
title_full_unstemmed Transcription-coupled mutagenesis by the DNA deaminase AID
title_short Transcription-coupled mutagenesis by the DNA deaminase AID
title_sort transcription-coupled mutagenesis by the dna deaminase aid
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395756/
https://www.ncbi.nlm.nih.gov/pubmed/15003109
work_keys_str_mv AT larsonerikd transcriptioncoupledmutagenesisbythednadeaminaseaid
AT maizelsnancy transcriptioncoupledmutagenesisbythednadeaminaseaid

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